Heather M Berens1,2, Kristen J Polinski1,2, Ted R Mikuls1,2, Sonia Khatter1,2, Justin August1,2, Ashley Visser1,2, Michael Mahler1,2, Michael H Weisman1,2, James R O'Dell1,2, Richard M Keating1,2, Jane H Buckner1,2, Peter K Gregersen1,2, Jill M Norris1,2, V Michael Holers1,2, Kevin D Deane1,2, M Kristen Demoruelle3,4. 1. From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado; Division of Rheumatology, University of Nebraska Medical Center, Omaha; Division of Rheumatology, Veterans Affairs (VA) Nebraska Western Iowa Health Care System, Omaha, Nebraska; Department of Research, Inova Diagnostics, San Diego; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles; Division of Rheumatology, Scripps Green Hospital, La Jolla, California; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA. 2. H.M. Berens, MD, PhD, Rheumatology Fellow, Division of Rheumatology, University of Colorado Anschutz Medical Campus; K.J. Polinski, BS, PhD student, Department of Epidemiology, Colorado School of Public Health; T.R. Mikuls, MD, MSPH, Professor of Medicine, Division of Rheumatology, University of Nebraska Medical Center, and Division of Rheumatology, VA Nebraska Western Iowa Health Care System; S. Khatter, MD, Resident, Division of Rheumatology, University of Colorado Anschutz Medical Campus; J. August, BS, Professional Research Assistant, Division of Rheumatology, University of Colorado Anschutz Medical Campus; A. Visser, BS, Professional Research Assistant, Division of Rheumatology, University of Colorado Anschutz Medical Campus; M. Mahler, PhD, Vice President of Research and Development, Department of Research, Inova Diagnostics; M.H. Weisman, MD, Professor of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center; J.R. O'Dell, MD, Professor and Vice Chair Internal Medicine, Chief of Rheumatology, Division of Rheumatology, University of Nebraska Medical Center; R.M. Keating, MD, Professor of Medicine, Division of Rheumatology, Scripps Green Hospital; J.H. Buckner, MD, President, Department of Immunology, Benaroya Research Institute at Virginia Mason; P.K. Gregersen, MD, Professor of Molecular Medicine, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research; J.M. Norris, PhD, Professor and Chair of Epidemiology, Department of Epidemiology, Colorado School of Public Health; V.M. Holers, MD, Professor of Medicine, Chair of Rheumatology, Division of Rheumatology, University of Colorado Anschutz Medical Campus; K.D. Deane, MD, PhD, Associate Professor of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus; M.K. Demoruelle, MD, PhD, Assistant Professor of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus. 3. From the Division of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado; Division of Rheumatology, University of Nebraska Medical Center, Omaha; Division of Rheumatology, Veterans Affairs (VA) Nebraska Western Iowa Health Care System, Omaha, Nebraska; Department of Research, Inova Diagnostics, San Diego; Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles; Division of Rheumatology, Scripps Green Hospital, La Jolla, California; Department of Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington; Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA. Kristen.Demoruelle@UCDenver.edu. 4. H.M. Berens, MD, PhD, Rheumatology Fellow, Division of Rheumatology, University of Colorado Anschutz Medical Campus; K.J. Polinski, BS, PhD student, Department of Epidemiology, Colorado School of Public Health; T.R. Mikuls, MD, MSPH, Professor of Medicine, Division of Rheumatology, University of Nebraska Medical Center, and Division of Rheumatology, VA Nebraska Western Iowa Health Care System; S. Khatter, MD, Resident, Division of Rheumatology, University of Colorado Anschutz Medical Campus; J. August, BS, Professional Research Assistant, Division of Rheumatology, University of Colorado Anschutz Medical Campus; A. Visser, BS, Professional Research Assistant, Division of Rheumatology, University of Colorado Anschutz Medical Campus; M. Mahler, PhD, Vice President of Research and Development, Department of Research, Inova Diagnostics; M.H. Weisman, MD, Professor of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center; J.R. O'Dell, MD, Professor and Vice Chair Internal Medicine, Chief of Rheumatology, Division of Rheumatology, University of Nebraska Medical Center; R.M. Keating, MD, Professor of Medicine, Division of Rheumatology, Scripps Green Hospital; J.H. Buckner, MD, President, Department of Immunology, Benaroya Research Institute at Virginia Mason; P.K. Gregersen, MD, Professor of Molecular Medicine, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research; J.M. Norris, PhD, Professor and Chair of Epidemiology, Department of Epidemiology, Colorado School of Public Health; V.M. Holers, MD, Professor of Medicine, Chair of Rheumatology, Division of Rheumatology, University of Colorado Anschutz Medical Campus; K.D. Deane, MD, PhD, Associate Professor of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus; M.K. Demoruelle, MD, PhD, Assistant Professor of Medicine, Division of Rheumatology, University of Colorado Anschutz Medical Campus. Kristen.Demoruelle@UCDenver.edu.
Abstract
OBJECTIVE: We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). METHODS: Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. RESULTS: In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. CONCLUSION: Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.
OBJECTIVE: We investigated the association of age and anticyclic citrullinated peptide antibodies (anti-CCP) in subjects without rheumatoid arthritis (RA). METHODS: Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDR) of patients with RA and 330 patients with osteoarthritis (OA). Individual isotypes (anti-CCP-IgA and anti-CCP-IgG) were also tested in all FDR. RESULTS: In FDR, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR 1.03) and anti-CCP-IgA (per year, OR 1.05) but not anti-CCP-IgG. In FDR and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50 years. CONCLUSION: Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity.
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