Literature DB >> 3098784

Enhancement of natural killer function through activation of the T11 E rosette receptor.

R E Schmidt, J M Michon, J Woronicz, S F Schlossman, E L Reinherz, J Ritz.   

Abstract

Natural killer (NK) cells, which represent a small fraction of normal peripheral blood mononuclear cells, were purified by immunofluorescent cell sorting of NKH1+ cells. cytotoxicity of NKH1+ cells could be enhanced through activation by monoclonal antibodies (anti-T11(2) and anti-T11(3)) specific for epitopes of the sheep erythrocyte receptor or by recombinant interleukin-2 (rIL-2). After 18 h, incubation with both anti-T11(2/3) and rIL-2 resulted in similar levels of enhanced cytotoxicity against NK-resistant as well as NK-sensitive targets. Before and after induction, cytotoxicity was found predominantly within the NKH1+ population. These results suggest that several distinct mechanisms may be capable of enhancing NK activity and that the cells responsible for lymphokine-activated killing are likely to be the same population capable of spontaneous or natural killing before activation in vitro.

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Year:  1987        PMID： 3098784      PMCID： PMC424050          DOI： 10.1172/JCI112800

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  20 in total

1.  Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

Authors:  D A Fox; R E Hussey; K A Fitzgerald; A Bensussan; J F Daley; S F Schlossman; E L Reinherz
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422

2.  Interleukin-2 augments natural killer cell activity.

Authors:  C S Henney; K Kuribayashi; D E Kern; S Gillis
Journal:  Nature       Date:  1981-05-28       Impact factor: 49.962

Review 3.  Human natural killer cells: biologic and pathologic aspects.

Authors:  G Trinchieri; B Perussia
Journal:  Lab Invest       Date:  1984-05       Impact factor: 5.662

4.  Specific release of proteoglycans from human natural killer cells during target lysis.

Authors:  R E Schmidt; R P MacDermott; G Bartley; M Bertovich; D A Amato; K F Austen; S F Schlossman; R L Stevens; J Ritz
Journal:  Nature       Date:  1985 Nov 21-27       Impact factor: 49.962

5.  Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein.

Authors:  R F Siliciano; J C Pratt; R E Schmidt; J Ritz; E L Reinherz
Journal:  Nature       Date:  1985 Oct 3-9       Impact factor: 49.962

6.  Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.

Authors:  S A Rosenberg; M T Lotze; L M Muul; S Leitman; A E Chang; S E Ettinghausen; Y L Matory; J M Skibber; E Shiloni; J T Vetto
Journal:  N Engl J Med       Date:  1985-12-05       Impact factor: 91.245

7.  The role of interleukin 2 and T11 E rosette antigen in activation and proliferation of human NK clones.

Authors:  R E Schmidt; T Hercend; D A Fox; A Bensussan; G Bartley; J F Daley; S F Schlossman; E L Reinherz; J Ritz
Journal:  J Immunol       Date:  1985-07       Impact factor: 5.422

8.  Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.

Authors:  T E Carey; T Takahashi; L A Resnick; H F Oettgen; L J Old
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

9.  Cell surface antigens of human renal cancer defined by autologous typing.

Authors:  R Ueda; H Shiku; M Pfreundschuh; T Takahashi; L T Li; W F Whitmore; H F Oettgen; L J Old
Journal:  J Exp Med       Date:  1979-09-19       Impact factor: 14.307

10.  Proliferative responses of circulating human NK cells: delineation of a unique pathway involving both direct and helper signals.

Authors:  A Ythier; L Delmon; E Reinherz; A Nowill; P Moingeon; Z Mishal; C Bohuon; T Hercend
Journal:  Eur J Immunol       Date:  1985-12       Impact factor: 5.532
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  11 in total

1.  Defect of a complement receptor 3 epitope in a patient with systemic lupus erythematosus.

Authors:  T Witte; F L Dumoulin; J E Gessner; J Schubert; O Götze; C Neumann; R F Todd; H Deicher; R E Schmidt
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

2.  Heterogeneity of human natural killer cells in the spleen.

Authors:  T Witte; K Wordelmann; R E Schmidt
Journal:  Immunology       Date:  1990-01       Impact factor: 7.397

3.  Requirements for the construction of antibody heterodimers for the direction of lysis of tumors by human T cells.

Authors:  C F Scott; W A Blättler; J M Lambert; R S Kalish; C Morimoto; S F Schlossman
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

4.  Production of granulocyte/macrophage-colony-stimulating factor by human natural killer cells. Modulation by the p75 subunit of the interleukin 2 receptor and by the CD2 receptor.

Authors:  L J Levitt; A Nagler; F Lee; J Abrams; M Shatsky; D Thompson
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

5.  Changes of natural killer cells during acute psychological stress.

Authors:  M Schedlowski; R Jacobs; G Stratmann; S Richter; A Hädicke; U Tewes; T O Wagner; R E Schmidt
Journal:  J Clin Immunol       Date:  1993-03       Impact factor: 8.317

6.  Later development of Fas ligand-mediated cytotoxicity as compared with granule-mediated cytotoxicity during the maturation of natural killer cells.

Authors:  T Nakazawa; K Agematsu; A Yabuhara
Journal:  Immunology       Date:  1997-10       Impact factor: 7.397

7.  Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.

Authors:  M A Caligiuri; C Murray; M J Robertson; E Wang; K Cochran; C Cameron; P Schow; M E Ross; T R Klumpp; R J Soiffer
Journal:  J Clin Invest       Date:  1993-01       Impact factor: 14.808

8.  Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells.

Authors:  W H Chambers; N L Vujanovic; A B DeLeo; M W Olszowy; R B Herberman; J C Hiserodt
Journal:  J Exp Med       Date:  1989-04-01       Impact factor: 14.307

9.  Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3.

Authors:  O Carpén; M L Dustin; T A Springer; J A Swafford; L A Beckett; J P Caulfield
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539

10.  Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.

Authors:  M J Robertson; R J Soiffer; S F Wolf; T J Manley; C Donahue; D Young; S H Herrmann; J Ritz
Journal:  J Exp Med       Date:  1992-03-01       Impact factor: 14.307
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