| Literature DB >> 30986486 |
Manuela A Hoffmann1, Helmut J Wieler2, Christian Baues3, Nicholas J Kuntz4, Ines Richardsen5, Mathias Schreckenberger6.
Abstract
Prostate-specific membrane antigen (PSMA) is a transmembrane protein with significantly increased expression in the cells and metastases of prostate carcinoma (CaP). PSMA-expression correlates with higher serum levels of prostate-specific antigen (PSA) and a higher Gleason score (GS). This finding has led to the development of novel imaging modalities such as 68Ga-/18F-labeled PSMA positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). This article reviews the literature pertaining to various new imaging technologies for the management of CaP. PSMA positron emission tomography/computed tomography appears to be an excellent diagnostic tool, that may drastically impact the management of a large number of patients with primary and recurrent CaP.Entities:
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Year: 2019 PMID: 30986486 DOI: 10.1016/j.urology.2019.04.004
Source DB: PubMed Journal: Urology ISSN: 0090-4295 Impact factor: 2.649