PURPOSE: The present study summarizes the first experience with Lu-PSMA-617 (Lu-PSMA) treatment in metastatic castration-resistant prostate cancer (PCa) in our institution. METHODS: This was an analysis of the first 30 consecutive patients who underwent Lu-PSMA therapy. Biochemical response was defined as prostate-specific antigen decrease of 50% or greater. Clinical toxicity was based on standardized physician's report, and biochemical and hematological toxicity was graded according to the Common Toxicity Criteria for Adverse Events (CTCAE) criteria. Clinical response was objectified in terms of severity of pain and usage of analgesics after separate treatment cycles. RESULTS: Thirty patients with advanced PCa received therapy cycles with 6 GBq Lu-PSMA (median, 4; range, 1-6). After the first cycle, usage of analgesics decreased in 45% of the patients. During treatment, maximum prostate-specific antigen decrease was 50% or greater and 90% or greater in 57% and 24% of the patients, respectively. Despite CTCAE grades III and IV anemia occurring in 2 patients (7%), all other newly originated biochemical toxicity was limited to maximum CTCAE grades I and II. Grade II xerostomia occurred in 17% of the patients. During a median follow-up length of 13.7 months (range, 9.8-32.3 months), median overall survival from start of the first therapy cycle was 11.3 months (range, 1.4-32.3 months). CONCLUSIONS: These results confirm the favorable safety and efficacy profile of Lu-PSMA, even up to 6 treatment cycles. Therefore, Lu-PSMA seems a promising therapeutic strategy for metastatic castration-resistant PCa patients. However, randomized controlled trials are warranted to obtain robust data.
PURPOSE: The present study summarizes the first experience with Lu-PSMA-617 (Lu-PSMA) treatment in metastatic castration-resistant prostate cancer (PCa) in our institution. METHODS: This was an analysis of the first 30 consecutive patients who underwent Lu-PSMA therapy. Biochemical response was defined as prostate-specific antigen decrease of 50% or greater. Clinical toxicity was based on standardized physician's report, and biochemical and hematological toxicity was graded according to the Common Toxicity Criteria for Adverse Events (CTCAE) criteria. Clinical response was objectified in terms of severity of pain and usage of analgesics after separate treatment cycles. RESULTS: Thirty patients with advanced PCa received therapy cycles with 6 GBq Lu-PSMA (median, 4; range, 1-6). After the first cycle, usage of analgesics decreased in 45% of the patients. During treatment, maximum prostate-specific antigen decrease was 50% or greater and 90% or greater in 57% and 24% of the patients, respectively. Despite CTCAE grades III and IV anemia occurring in 2 patients (7%), all other newly originated biochemical toxicity was limited to maximum CTCAE grades I and II. Grade II xerostomia occurred in 17% of the patients. During a median follow-up length of 13.7 months (range, 9.8-32.3 months), median overall survival from start of the first therapy cycle was 11.3 months (range, 1.4-32.3 months). CONCLUSIONS: These results confirm the favorable safety and efficacy profile of Lu-PSMA, even up to 6 treatment cycles. Therefore, Lu-PSMA seems a promising therapeutic strategy for metastatic castration-resistant PCa patients. However, randomized controlled trials are warranted to obtain robust data.
Authors: Finn Edler von Eyben; Glenn Bauman; Rie von Eyben; Kambiz Rahbar; Cigdem Soydal; Alexander R Haug; Irene Virgolini; Harshad Kulkarni; Richard Baum; Giovanni Paganelli Journal: Int J Mol Sci Date: 2020-11-28 Impact factor: 5.923
Authors: Mohammad S Sadaghiani; Sara Sheikhbahaei; Rudolf A Werner; Kenneth J Pienta; Martin G Pomper; Michael A Gorin; Lilja B Solnes; Steven P Rowe Journal: Prostate Date: 2022-03-14 Impact factor: 4.012
Authors: Esmée C A van der Sar; Adinda J S Kühr; Sander C Ebbers; Andrew M Henderson; Bart de Keizer; Marnix G E H Lam; Arthur J A T Braat Journal: Biomedicines Date: 2022-07-01
Authors: Bastiaan M Privé; Marcel J R Janssen; Inge M van Oort; Constantijn H J Muselaers; Marianne A Jonker; Michel de Groot; Niven Mehra; J Fred Verzijlbergen; Tom W J Scheenen; Patrik Zámecnik; Jelle O Barentsz; Martin Gotthardt; Walter Noordzij; Wouter V Vogel; Andries M Bergman; Henk G van der Poel; André N Vis; Daniela E Oprea-Lager; Winald R Gerritsen; J Alfred Witjes; James Nagarajah Journal: BMC Cancer Date: 2020-09-14 Impact factor: 4.430