Rebecca Byrd1, Patrick Smith2, Omar Mohamedaly3, Laurie D Snyder3, Amy M Pastva4. 1. Duke University Health System, Department of Physical and Occupational Therapy. 2. Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences. 3. Duke University School of Medicine, Department of Medicine. 4. Duke University School of Medicine, Departments of Orthopaedic Surgery, Medicine, Cell Biology.
Abstract
PURPOSE: Rehabilitation can improve health outcomes in candidates for lung transplantation. The purpose of this study was to retrospectively evaluate the effect of a one-month physical therapy (PT)-based outpatient program on exercise capacity, symptoms, quality of life and examine predictors of functional outcome changes in adults awaiting lung transplantation. METHODS: Participants (n=141) completed a 23-session exercise and educational program over one month. Outcomes included 6-minute walk distance (6MWD), San Diego Shortness of Breath Questionnaire (SOBQ), Center for Epidemiological Studies-Depression Scale (CESD), and Ferrans and Powers Quality of Life Index Pulmonary Version III (QOL). RESULTS: Participants were older (median age 63) with restrictive (59%) or obstructive (24%) disease. Moderate-to-large improvements in 6MWD were observed (69 m, p < 0.001, d = 0.72), independent of demographics, symptoms, and QOL. Lower initial 6MWD and lower oxygen utilization were associated with greater 6MWD improvements, with largest gains occurring in initial 6MWD < 305 m. Small-to-moderate improvements were observed on CESD (p < 0.001, d = 0.26) and in overall QOL (p < 0.001, d = 0.27), with a non-significant improvement observed on SOBQ (p = 0.248, d = 0.13). CONCLUSIONS: Completion of a one-month PT-based outpatient rehabilitation program was associated with improved exercise capacity, depressive symptoms and QOL.
PURPOSE: Rehabilitation can improve health outcomes in candidates for lung transplantation. The purpose of this study was to retrospectively evaluate the effect of a one-month physical therapy (PT)-based outpatient program on exercise capacity, symptoms, quality of life and examine predictors of functional outcome changes in adults awaiting lung transplantation. METHODS: Participants (n=141) completed a 23-session exercise and educational program over one month. Outcomes included 6-minute walk distance (6MWD), San Diego Shortness of Breath Questionnaire (SOBQ), Center for Epidemiological Studies-Depression Scale (CESD), and Ferrans and Powers Quality of Life Index Pulmonary Version III (QOL). RESULTS: Participants were older (median age 63) with restrictive (59%) or obstructive (24%) disease. Moderate-to-large improvements in 6MWD were observed (69 m, p < 0.001, d = 0.72), independent of demographics, symptoms, and QOL. Lower initial 6MWD and lower oxygen utilization were associated with greater 6MWD improvements, with largest gains occurring in initial 6MWD < 305 m. Small-to-moderate improvements were observed on CESD (p < 0.001, d = 0.26) and in overall QOL (p < 0.001, d = 0.27), with a non-significant improvement observed on SOBQ (p = 0.248, d = 0.13). CONCLUSIONS: Completion of a one-month PT-based outpatient rehabilitation program was associated with improved exercise capacity, depressive symptoms and QOL.
Entities:
Keywords:
exercise; rehabilitation; six-minute walk distance
Authors: Michael Patrick Tuppin; Jennifer D Paratz; Angela T Chang; Helen E Seale; James R Walsh; Fiona D Kermeeen; Keith D McNeil; Peter M Hopkins Journal: J Heart Lung Transplant Date: 2008-05-19 Impact factor: 10.247
Authors: James A Blumenthal; Michael A Babyak; Francis J Keefe; R Duane Davis; Rick A Lacaille; Robert M Carney; Kenneth E Freedland; Elbert Trulock; Scott M Palmer Journal: J Consult Clin Psychol Date: 2006-06
Authors: Steven M Kawut; Mitchell K O'Shea; Matthew N Bartels; Jessie S Wilt; Joshua R Sonett; Selim M Arcasoy Journal: Respir Med Date: 2005-11 Impact factor: 3.415
Authors: Juan Pablo de Torres; Victor Pinto-Plata; Edward Ingenito; Peter Bagley; Anthony Gray; Robert Berger; Bartolome Celli Journal: Chest Date: 2002-04 Impact factor: 9.410
Authors: T Martinu; M A Babyak; C F O'Connell; R M Carney; E P Trulock; R D Davis; J A Blumenthal; S M Palmer Journal: Am J Transplant Date: 2008-07 Impact factor: 8.086
Authors: Joanna M Schaenman; Joshua M Diamond; John R Greenland; Cynthia Gries; Cassie C Kennedy; Amit D Parulekar; Dmitry Rozenberg; Jonathan P Singer; Lianne G Singer; Laurie D Snyder; Sangeeta Bhorade Journal: Am J Transplant Date: 2020-12-24 Impact factor: 9.369