Sarah N Adams1, Margaret A Adgent2, Tebeb Gebretsadik3, Terryl J Hartman4, Shanda Vereen2, Christina Ortiz1, Frances A Tylavsky5, Kecia N Carroll2. 1. Division of Allergy and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. 2. Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. 3. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. 4. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. 5. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Abstract
Background: Maternal vitamin D status during pregnancy may influence lung development and risk of childhood wheeze and asthma. We investigated the relationship between prenatal vitamin D and child asthma in a racially diverse cohort with a high burden of vitamin D insufficiency and child asthma.Materials and methods: We included mother-child dyads in the prenatal Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) cohort (2006-2011, Shelby County, Tennessee). Maternal plasma vitamin D [25(OH)D] was measured from second trimester (n = 1091) and delivery specimens (n = 907). At age 4-6 years, we obtained parent report of current child wheeze (symptoms within the past 12 months) and asthma (physician diagnosis and/or medication or symptoms within the past 12 months). We used multivariable logistic regression to assess associations of 25(OH)D and child wheeze/asthma, including an interaction term for maternal race. Results: Median second trimester 25(OH)D levels were 25.1 and 19.1 ng/ml in White (n = 366) and Black women (N = 725), respectively. We detected significant interactions by maternal race for second-trimester plasma 25(OH)D and child current wheeze (p = .014) and asthma (p = .011). Odds of current wheeze and asthma decreased with increasing 25(OH)D in dyads with White mothers and increased in dyads with Black mothers, e.g. adjusted odds ratio (95% confidence interval) for asthma: 0.63 (0.36-1.09) and 1.41 (1.01-1.97) per interquartile range (15-27 ng/ml 25[OH]D) increase, respectively. At delivery, protective associations in White dyads were attenuated. Conclusion: We detected effect modification by maternal race in associations between prenatal 25(OH)D and child wheeze/asthma. Further research in racially diverse populations is needed.
Background: Maternal vitamin D status during pregnancy may influence lung development and risk of childhood wheeze and asthma. We investigated the relationship between prenatal vitamin D and child asthma in a racially diverse cohort with a high burden of vitamin D insufficiency and child asthma.Materials and methods: We included mother-child dyads in the prenatal Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) cohort (2006-2011, Shelby County, Tennessee). Maternal plasma vitamin D [25(OH)D] was measured from second trimester (n = 1091) and delivery specimens (n = 907). At age 4-6 years, we obtained parent report of current child wheeze (symptoms within the past 12 months) and asthma (physician diagnosis and/or medication or symptoms within the past 12 months). We used multivariable logistic regression to assess associations of 25(OH)D and child wheeze/asthma, including an interaction term for maternal race. Results: Median second trimester 25(OH)D levels were 25.1 and 19.1 ng/ml in White (n = 366) and Black women (N = 725), respectively. We detected significant interactions by maternal race for second-trimester plasma 25(OH)D and child current wheeze (p = .014) and asthma (p = .011). Odds of current wheeze and asthma decreased with increasing 25(OH)D in dyads with White mothers and increased in dyads with Black mothers, e.g. adjusted odds ratio (95% confidence interval) for asthma: 0.63 (0.36-1.09) and 1.41 (1.01-1.97) per interquartile range (15-27 ng/ml 25[OH]D) increase, respectively. At delivery, protective associations in White dyads were attenuated. Conclusion: We detected effect modification by maternal race in associations between prenatal 25(OH)D and child wheeze/asthma. Further research in racially diverse populations is needed.
Authors: A Roy; M Kocak; T J Hartman; S Vereen; M Adgent; C Piyathilake; F A Tylavsky; K N Carroll Journal: Pediatr Allergy Immunol Date: 2017-12-19 Impact factor: 6.377
Authors: Helene M Wolsk; Benjamin J Harshfield; Nancy Laranjo; Vincent J Carey; George O'Connor; Megan Sandel; Robert C Strunk; Leonard B Bacharier; Robert S Zeiger; Michael Schatz; Bruce W Hollis; Scott T Weiss; Augusto A Litonjua Journal: J Allergy Clin Immunol Date: 2017-03-09 Impact factor: 10.793
Authors: Rebeccah A McKibben; Di Zhao; Pamela L Lutsey; Andrea L C Schneider; Eliseo Guallar; Thomas H Mosley; Erin D Michos Journal: J Clin Endocrinol Metab Date: 2015-10-28 Impact factor: 5.958
Authors: Augusto A Litonjua; Vincent J Carey; Nancy Laranjo; Benjamin J Harshfield; Thomas F McElrath; George T O'Connor; Megan Sandel; Ronald E Iverson; Aviva Lee-Paritz; Robert C Strunk; Leonard B Bacharier; George A Macones; Robert S Zeiger; Michael Schatz; Bruce W Hollis; Eve Hornsby; Catherine Hawrylowicz; Ann Chen Wu; Scott T Weiss Journal: JAMA Date: 2016-01-26 Impact factor: 56.272
Authors: Alvin T Kho; Sunita Sharma; Weiliang Qiu; Roger Gaedigk; Barbara Klanderman; Simin Niu; Chris Anderson; James S Leeder; Scott T Weiss; Kelan G Tantisira Journal: BMC Med Genomics Date: 2013-11-05 Impact factor: 3.063
Authors: Frances A Tylavsky; Mehmet Kocak; Laura E Murphy; J Carolyn Graff; Frederick B Palmer; Eszter Völgyi; Alicia M Diaz-Thomas; Robert J Ferry Journal: Nutrients Date: 2015-12-02 Impact factor: 5.717
Authors: Helene M Wolsk; Bo L Chawes; Augusto A Litonjua; Bruce W Hollis; Johannes Waage; Jakob Stokholm; Klaus Bønnelykke; Hans Bisgaard; Scott T Weiss Journal: PLoS One Date: 2017-10-27 Impact factor: 3.240