Shiyao Wang1, Shaoce Xu1, Zhengwei Shi1, Jianchao Wu1, Shuanhu Lei2, Yuliang Wang3. 1. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China;Orthopedics Key Laboratory of Gansu Province, Lanzhou Gansu, 730000, P.R.China. 2. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China. 3. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou Gansu, 730000, P.R.China.wyl60918@sina.com.
Abstract
OBJECTIVE: To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases. METHODS: The relevant research results at home and abroad in recent years were analyzed and summarized. RESULTS: CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction. CONCLUSION: At present, the research on the mechanism of CGRP and RANK/RANKL/OPG system in bone reconstruction is insufficient. Therefore, it is necessary to study further on the process and interrelation of CGRP and RANK/RANKL/OPG system in bone reconstruction to confirm their mechanism, which will bring new ideas and methods for the treatment of bone related diseases in clinic.
OBJECTIVE: To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases. METHODS: The relevant research results at home and abroad in recent years were analyzed and summarized. RESULTS: CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction. CONCLUSION: At present, the research on the mechanism of CGRP and RANK/RANKL/OPG system in bone reconstruction is insufficient. Therefore, it is necessary to study further on the process and interrelation of CGRP and RANK/RANKL/OPG system in bone reconstruction to confirm their mechanism, which will bring new ideas and methods for the treatment of bone related diseases in clinic.
Entities:
Keywords:
Bone reconstruction; calcitonin gene-related peptide; osteoblast; osteoclast; osteoprotegerin; receptor activator of nuclear factor κB; receptor activator of nuclear factor κB ligand
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