Yuanyuan Li1, Bingdong Sui2, Christian Dahl3, Brian Bergeron3, Peter Shipman4, Lina Niu5, Jihua Chen6, Franklin R Tay7. 1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, PR China. 2. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, PR China; State Key Laboratory of Military Stomatology & Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, PR China. 3. Department of Endodontics, The Dental College of Georgia, Augusta University, 1430, John Wesley Gilbert Drive, Augusta, GA 30912-1129, USA. 4. Greenblatt Library, Augusta University, 1430, John Wesley Gilbert Drive, Augusta, GA 30912-1129, USA. 5. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, PR China; Department of Endodontics, The Dental College of Georgia, Augusta University, 1430, John Wesley Gilbert Drive, Augusta, GA 30912-1129, USA. Electronic address: niulina831013@126.com. 6. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, PR China; Department of Endodontics, The Dental College of Georgia, Augusta University, 1430, John Wesley Gilbert Drive, Augusta, GA 30912-1129, USA. Electronic address: jhchen@fmmu.edu.cn. 7. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, PR China; Department of Endodontics, The Dental College of Georgia, Augusta University, 1430, John Wesley Gilbert Drive, Augusta, GA 30912-1129, USA. Electronic address: ftay@augusta.edu.
Abstract
OBJECTIVES: The most commonly-accepted strategy for managing irreversible pulpitis, an irreversible condition of dental pulp inflammation, is root canal treatment, which is limited by high costs and complex techniques. High success rates have been reported for the use of pulpotomy in managing pulp exposure resulting from extensive caries. The objective of the present work was to evaluate the effectiveness and cost-effectiveness of pulpotomy and associated medicaments in saving permanent teeth with pulp exposure resulting from extensive caries. SOURCES: Multiple databases were searched on January 12, 2019, without limitations on the language or year of publication. STUDY SELECTION: Randomized controlled trials comparing pulpotomy with alternative treatments, or comparing two or more medicaments in pulpotomy for permanent teeth with carious pulp exposure were included. DATA: Seventeen studies reported in 21 articles were included. Intention-to-treat analyses on studies comparing pulpotomy and other treatment modalities tended to favor pulpotomy. Meta-analysis was not performed on comparisons of pulpotomy and other treatments because of the limited number of studies. Most evidence on comparisons among different pulpotomy medicaments was found in trials comparing mineral trioxide aggregate (MTA) and calcium hydroxide, with the results of meta-analyses favoring MTA. Data were insufficient to determine the cost-effectiveness of successful modality. CONCLUSIONS: Pulpotomy is a prospective substitute for root canal treatment in managing permanent teeth with carious pulp exposures, even in permanent teeth with irreversible pulpitis. Large, well-designed trials comparing pulpotomy with other treatments in terms of cost-effectiveness should be informative. CLINICAL SIGNIFICANCE: The success of pulpotomy in managing irreversible pulpitis challenges the rhetoric that irreversible pulpitis can only be managed by root canal treatment. Cost-effectiveness analysis rather than analysis on effectiveness of treatment outcome alone should be considered in all health care domains to evaluate the benefits of alternative treatment options.
OBJECTIVES: The most commonly-accepted strategy for managing irreversible pulpitis, an irreversible condition of dental pulp inflammation, is root canal treatment, which is limited by high costs and complex techniques. High success rates have been reported for the use of pulpotomy in managing pulp exposure resulting from extensive caries. The objective of the present work was to evaluate the effectiveness and cost-effectiveness of pulpotomy and associated medicaments in saving permanent teeth with pulp exposure resulting from extensive caries. SOURCES: Multiple databases were searched on January 12, 2019, without limitations on the language or year of publication. STUDY SELECTION: Randomized controlled trials comparing pulpotomy with alternative treatments, or comparing two or more medicaments in pulpotomy for permanent teeth with carious pulp exposure were included. DATA: Seventeen studies reported in 21 articles were included. Intention-to-treat analyses on studies comparing pulpotomy and other treatment modalities tended to favor pulpotomy. Meta-analysis was not performed on comparisons of pulpotomy and other treatments because of the limited number of studies. Most evidence on comparisons among different pulpotomy medicaments was found in trials comparing mineral trioxide aggregate (MTA) and calcium hydroxide, with the results of meta-analyses favoring MTA. Data were insufficient to determine the cost-effectiveness of successful modality. CONCLUSIONS: Pulpotomy is a prospective substitute for root canal treatment in managing permanent teeth with carious pulp exposures, even in permanent teeth with irreversible pulpitis. Large, well-designed trials comparing pulpotomy with other treatments in terms of cost-effectiveness should be informative. CLINICAL SIGNIFICANCE: The success of pulpotomy in managing irreversible pulpitis challenges the rhetoric that irreversible pulpitis can only be managed by root canal treatment. Cost-effectiveness analysis rather than analysis on effectiveness of treatment outcome alone should be considered in all health care domains to evaluate the benefits of alternative treatment options.
Authors: Paulo J Palma; Joana A Marques; Márcia Antunes; Rui I Falacho; Diana Sequeira; Luís Roseiro; João Miguel Santos; João C Ramos Journal: Clin Oral Investig Date: 2020-10-12 Impact factor: 3.573
Authors: Flavia Iaculli; Francisco Javier Rodríguez-Lozano; Benjamín Briseño-Marroquín; Thomas Gerhard Wolf; Gianrico Spagnuolo; Sandro Rengo Journal: J Clin Med Date: 2022-07-11 Impact factor: 4.964