D Piña-Fuentes1, J M C van Dijk2, G Drost1, J C van Zijl3, T van Laar2, M A J Tijssen2, M Beudel4. 1. Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. 2. Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. 3. Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. 4. Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Neurology, Amsterdam UMC, University of Amsterdam, Netherlands. Electronic address: m.beudel@amc.uva.nl.
Abstract
OBJECTIVE: To outline the current knowledge of (sub)cortical oscillations in Parkinson's Disease (PD) and dystonia, and to quantitatively summarize the results of direct comparisons of local oscillatory power between both diseases in the resting state, without medication or stimulation, in both the low-frequency (LF, ±4-12 Hz) and beta (±13 to ∼30 Hz) range. METHODS: Eight relevant studies were included. Recordings from 127 dystonia-, and 144 PD-patient hemispheres were analyzed. Ratios of LF and beta power between diseases were obtained. RESULTS: Beta oscillations in dystonia were lower when compared to beta oscillations in PD, ratio = 0.72, Z = 3.56, p = 0.0004, 95% CI [0.60, 0.86]. Subgroup analyses showed significant differences only in the GPi, whilst conflicting evidence was shown in the STN. LF oscillations in PD were lower when compared to LF oscillations in dystonia, ratio = 0.77, Z = 2.45, p = 0.01, 95% CI [0.63, 0.95]. Subgroup analyses showed significant differences in the GPi and the STN, but not in the M1. CONCLUSIONS: LF and beta oscillations are present in the resting-state motor network of both PD and dystonia patients. However, the power distribution of those oscillations differs between diseases. SIGNIFICANCE: This meta-analysis provides high-level evidence which supports the presence of exaggerated oscillations across the parkinsonian/dystonic motor networks.
OBJECTIVE: To outline the current knowledge of (sub)cortical oscillations in Parkinson's Disease (PD) and dystonia, and to quantitatively summarize the results of direct comparisons of local oscillatory power between both diseases in the resting state, without medication or stimulation, in both the low-frequency (LF, ±4-12 Hz) and beta (±13 to ∼30 Hz) range. METHODS: Eight relevant studies were included. Recordings from 127 dystonia-, and 144 PD-patient hemispheres were analyzed. Ratios of LF and beta power between diseases were obtained. RESULTS: Beta oscillations in dystonia were lower when compared to beta oscillations in PD, ratio = 0.72, Z = 3.56, p = 0.0004, 95% CI [0.60, 0.86]. Subgroup analyses showed significant differences only in the GPi, whilst conflicting evidence was shown in the STN. LF oscillations in PD were lower when compared to LF oscillations in dystonia, ratio = 0.77, Z = 2.45, p = 0.01, 95% CI [0.63, 0.95]. Subgroup analyses showed significant differences in the GPi and the STN, but not in the M1. CONCLUSIONS: LF and beta oscillations are present in the resting-state motor network of both PD and dystoniapatients. However, the power distribution of those oscillations differs between diseases. SIGNIFICANCE: This meta-analysis provides high-level evidence which supports the presence of exaggerated oscillations across the parkinsonian/dystonic motor networks.
Authors: Joseph W Olson; Arie Nakhmani; Zachary T Irwin; Lloyd J Edwards; Christopher L Gonzalez; Melissa H Wade; Sarah D Black; Mohammad Z Awad; Daniel J Kuhman; Christopher P Hurt; Bart L Guthrie; Harrison C Walker Journal: Mov Disord Date: 2022-06-14 Impact factor: 9.698
Authors: Adolfo Ramirez-Zamora; James Giordano; Aysegul Gunduz; Jose Alcantara; Jackson N Cagle; Stephanie Cernera; Parker Difuntorum; Robert S Eisinger; Julieth Gomez; Sarah Long; Brandon Parks; Joshua K Wong; Shannon Chiu; Bhavana Patel; Warren M Grill; Harrison C Walker; Simon J Little; Ro'ee Gilron; Gerd Tinkhauser; Wesley Thevathasan; Nicholas C Sinclair; Andres M Lozano; Thomas Foltynie; Alfonso Fasano; Sameer A Sheth; Katherine Scangos; Terence D Sanger; Jonathan Miller; Audrey C Brumback; Priya Rajasethupathy; Cameron McIntyre; Leslie Schlachter; Nanthia Suthana; Cynthia Kubu; Lauren R Sankary; Karen Herrera-Ferrá; Steven Goetz; Binith Cheeran; G Karl Steinke; Christopher Hess; Leonardo Almeida; Wissam Deeb; Kelly D Foote; Michael S Okun Journal: Front Hum Neurosci Date: 2020-03-27 Impact factor: 3.169