M Ezura1, A Kikuchi1, A Ishiki2, N Okamura3,4, T Hasegawa1, R Harada4, S Watanuki5, Y Funaki6, K Hiraoka5, T Baba1, N Sugeno1, R Oshima1, S Yoshida1, J Kobayashi1, M Kobayashi7, O Tano8, I Nakashima1,7, S Mugikura9, R Iwata6, Y Taki10, K Furukawa2,11, H Arai2, S Furumoto6, M Tashiro5, K Yanai4, Y Kudo12, A Takeda13, M Aoki1. 1. Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. 2. Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 3. Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. 4. Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan. 5. Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan. 6. Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan. 7. Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. 8. Department of Neurology, Sendai Medical Center, Sendai, Japan. 9. Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan. 10. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 11. Division of Community of Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. 12. Division of Neuroimaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 13. Department of Neurology, National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.
Abstract
BACKGROUND AND PURPOSE: Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders, 18 F-THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B. In this study, the aim was to investigate the progression of disease-related pathology in the brains of patients with CBS using positron emission tomography with 18 F-THK5351. METHODS: Baseline and 1-year follow-up imaging were acquired using magnetic resonance imaging and positron emission tomography with 18 F-THK5351 in 10 subjects: five patients with CBS and five age-matched normal controls (NCs). RESULTS: The 1-year follow-up scan images revealed that 18 F-THK5351 retention had significantly increased in the superior parietal gyrus of the patients with CBS compared with the NCs. The median increases in 18 F-THK5351 accumulation in the patients with CBS were 6.53% in the superior parietal gyrus, 4.34% in the precentral gyrus and 4.33% in the postcentral gyrus. In contrast, there was no significant increase in the regional 18 F-THK5351 retention in the NCs. CONCLUSIONS: Longitudinal increases in 18 F-THK5351 binding can be detected over a short interval in the cortical sites of patients with CBS. A monoamine oxidase B binding radiotracer could be useful in monitoring the progression of astrogliosis in CBS.
BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders, 18 F-THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B. In this study, the aim was to investigate the progression of disease-related pathology in the brains of patients with CBS using positron emission tomography with 18 F-THK5351. METHODS: Baseline and 1-year follow-up imaging were acquired using magnetic resonance imaging and positron emission tomography with 18 F-THK5351 in 10 subjects: five patients with CBS and five age-matched normal controls (NCs). RESULTS: The 1-year follow-up scan images revealed that 18 F-THK5351 retention had significantly increased in the superior parietal gyrus of the patients with CBS compared with the NCs. The median increases in 18 F-THK5351 accumulation in the patients with CBS were 6.53% in the superior parietal gyrus, 4.34% in the precentral gyrus and 4.33% in the postcentral gyrus. In contrast, there was no significant increase in the regional 18 F-THK5351 retention in the NCs. CONCLUSIONS: Longitudinal increases in 18 F-THK5351 binding can be detected over a short interval in the cortical sites of patients with CBS. A monoamine oxidase B binding radiotracer could be useful in monitoring the progression of astrogliosis in CBS.
Authors: Maria Stamelou; Gesine Respondek; Nikolaos Giagkou; Jennifer L Whitwell; Gabor G Kovacs; Günter U Höglinger Journal: Nat Rev Neurol Date: 2021-08-23 Impact factor: 42.937
Authors: Min Young Chun; Jongmin Lee; Jee Hyang Jeong; Jee Hoon Roh; Seung Jun Oh; Minyoung Oh; Jungsu S Oh; Jae Seung Kim; Seung Hwan Moon; Sook-Young Woo; Young Ju Kim; Yeong Sim Choe; Hee Jin Kim; Duk L Na; Hyemin Jang; Sang Won Seo Journal: Yonsei Med J Date: 2022-03 Impact factor: 2.759