Divya Yerramilli1, Lorraine Drapek2, Ryan D Nipp3, Nora Horick4, Samantha M C Moran3, Bridget Noé2, Sara M D'Arpino3, Devarati Mitra2, Theodore S Hong2, David P Ryan3, Don S Dizon5, Jennifer Wo2. 1. Department of Radiation Oncology, Massachusetts General Hospital, Lunder LL2, 55 Fruit Street, Boston, MA, 02114, USA. DYERRAMILLI@BWH.HARVARD.EDU. 2. Department of Radiation Oncology, Massachusetts General Hospital, Lunder LL2, 55 Fruit Street, Boston, MA, 02114, USA. 3. Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Boston, MA, USA. 4. Massachusetts General Hospital Biostatistics Center, Boston, MA, USA. 5. Division of Medical Oncology, Department of Medicine, Lifespan Cancer Institute, Rhode Island Hospital, Providence, RI, USA.
Abstract
PURPOSE/OBJECTIVE(S): Definitive chemoradiation (CRT) results in high cure rates of anal cancer, with advanced radiation (RT) techniques improving toxicity. However, there is limited data regarding these patients' sexual function (SF), quality of life (QOL), and mood. We hypothesized that anal cancer treatment would result in detrimental effects on SF, QOL, and mood. MATERIALS/ METHODS: We prospectively surveyed patients with anal cancer treated with definitive CRT. We assessed SF for women with the Female Sexual Function Index (FSFI) and for men with the International Index of Erectile Function (IIEF). For all patients, we assessed QOL using EORTC QLQ-C30 and CR29 and mood using the Hospital Anxiety and Depression Scale (HADS). We reported descriptive statistics for SF, QOL, and mood and used univariate analysis to evaluate predictors of SF for women. RESULTS: Of 50 eligible patients, 84% completed the surveys. Median time from RT until survey was 36 months (1-97 months). Women (n = 34) reported poor SF overall (mean FSFI score = 15, scale 2-36, standard deviation (SD) 10.4). Most women reported poor SF related to satisfaction, desire, orgasm, arousal, pain, and lubrication. Men (n = 8) also had poor overall satisfaction (mean IIEF score = 6.1, scale 2-10, SD 3.6). Men reported poor erectile function and lower satisfaction with intercourse. Mean QLQ-C30 QOL score was 86.5 (SD 16.3). Results from EORTC QLQ-CR-20 demonstrated patients experienced poor sexual interest. Per HADS, 2.5% reported depression and 18% anxiety. CONCLUSION: Patients with anal cancer experience sexual dysfunction after RT, with QOL and mood symptoms similar to patients with other cancers. Our data support the need for ongoing efforts to understand and address issues with SF, QOL, and mood following RT for these patients.
PURPOSE/OBJECTIVE(S): Definitive chemoradiation (CRT) results in high cure rates of anal cancer, with advanced radiation (RT) techniques improving toxicity. However, there is limited data regarding these patients' sexual function (SF), quality of life (QOL), and mood. We hypothesized that anal cancer treatment would result in detrimental effects on SF, QOL, and mood. MATERIALS/ METHODS: We prospectively surveyed patients with anal cancer treated with definitive CRT. We assessed SF for women with the Female Sexual Function Index (FSFI) and for men with the International Index of Erectile Function (IIEF). For all patients, we assessed QOL using EORTC QLQ-C30 and CR29 and mood using the Hospital Anxiety and Depression Scale (HADS). We reported descriptive statistics for SF, QOL, and mood and used univariate analysis to evaluate predictors of SF for women. RESULTS: Of 50 eligible patients, 84% completed the surveys. Median time from RT until survey was 36 months (1-97 months). Women (n = 34) reported poor SF overall (mean FSFI score = 15, scale 2-36, standard deviation (SD) 10.4). Most women reported poor SF related to satisfaction, desire, orgasm, arousal, pain, and lubrication. Men (n = 8) also had poor overall satisfaction (mean IIEF score = 6.1, scale 2-10, SD 3.6). Men reported poor erectile function and lower satisfaction with intercourse. Mean QLQ-C30 QOL score was 86.5 (SD 16.3). Results from EORTC QLQ-CR-20 demonstrated patients experienced poor sexual interest. Per HADS, 2.5% reported depression and 18% anxiety. CONCLUSION: Patients with anal cancer experience sexual dysfunction after RT, with QOL and mood symptoms similar to patients with other cancers. Our data support the need for ongoing efforts to understand and address issues with SF, QOL, and mood following RT for these patients.
Entities:
Keywords:
Anal cancer; Anxiety; Depression; Mood; Quality of life; Sexual function
Authors: Jeanne Carter; Cara Stabile; Barbara Seidel; Raymond E Baser; Abigail R Gunn; Stephanie Chi; Rebecca F Steed; Shari Goldfarb; Deborah J Goldfrank Journal: Support Care Cancer Date: 2015-01-08 Impact factor: 3.603
Authors: R N Whistance; T Conroy; W Chie; A Costantini; O Sezer; M Koller; C D Johnson; S A Pilkington; J Arraras; E Ben-Josef; A M Pullyblank; P Fayers; J M Blazeby Journal: Eur J Cancer Date: 2009-09-16 Impact factor: 9.162
Authors: Bello Arkilla Magaji; Foong Ming Moy; April Camilla Roslani; Chee Wei Law; Farhana Raduan; Ismail Sagap Journal: Asian Pac J Cancer Prev Date: 2015
Authors: Prajnan Das; Scott B Cantor; Crystal L Parker; Joan B Zampieri; Andrew Baschnagel; Cathy Eng; Marc E Delclos; Sunil Krishnan; Nora A Janjan; Christopher H Crane Journal: Cancer Date: 2010-02-15 Impact factor: 6.860
Authors: Kathy Han; Bernard J Cummings; Patricia Lindsay; Julia Skliarenko; Tim Craig; Lisa W Le; James Brierley; Rebecca Wong; Robert Dinniwell; Andrew J Bayley; Laura A Dawson; Jolie Ringash; Monika K Krzyzanowska; Malcolm J Moore; Eric X Chen; Alexandra M Easson; Zahra Kassam; Charles Cho; John Kim Journal: Int J Radiat Oncol Biol Phys Date: 2014-09-03 Impact factor: 7.038
Authors: Deborah C Marshall; Elizabeth S Tarras; Ayesha Ali; Julie Bloom; Mylin A Torres; Jenna M Kahn Journal: CA Cancer J Clin Date: 2022-03-17 Impact factor: 286.130
Authors: Damiano Pizzol; Tao Xiao; Lee Smith; Guillermo F López Sánchez; Andrea Garolla; Christopher Parris; Yvonne Barnett; Petre Cristian Ilie; Pinar Soysal; Jae Il Shin; Mark A Tully; Lin Yang; Nicola Veronese; Igor Grabovac Journal: Br J Gen Pract Date: 2021-04-29 Impact factor: 5.386