Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 [Ketamine in the therapy of chronic pain and depression].

Literature DB >> 30980201

[Ketamine in the therapy of chronic pain and depression].

Wolfgang Jaksch^1,2, Rudolf Likar^3,4,5, Martin Aigner^3,6.

Abstract

Although ketamine has been known and clinically applied for a long time, questions still arise around the many possible indications in which the anesthetic and analgesic substance could be used. In particular, these questions relate to new indications in which ketamine is used in low subanesthetic doses.The mechanism of action at the NMDA receptor clearly distinguishes ketamine from all other analgesics. Possible applications include the prevention of chronic postoperative pain as well as the treatment of neuropathic pain. With the treatment of refractory depression completely new therapeutic areas for ketamine could be established.

Entities: Chemical Disease

Keywords: Cancer pain; Neuropathic pain; Pain therapy; S-Ketamine; Therapy resistant depression

Mesh：

Substances：
Analgesics
Ketamine

Year: 2019 PMID： 30980201 DOI： 10.1007/s10354-019-0695-x

Source DB: PubMed Journal: Wien Med Wochenschr ISSN： 0043-5341

Keyword Cloud
References

57 in total

1. New use for an old drug: oral ketamine for treatment-resistant depression.

Authors: Kevin M Swiatek; Kim Jordan; Julie Coffman
Journal: BMJ Case Rep Date: 2016-08-03

2. Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial.

Authors: Flavia Karine Rigo; Gabriela Trevisan; Maria C Godoy; Mateus Fortes Rossato; Gerusa D Dalmolin; Mariane A Silva; Mirian S Menezes; Wolnei Caumo; Juliano Ferreira
Journal: Pain Physician Date: 2017-03 Impact factor: 4.965

Review 3. A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.

Authors: Marie Naughton; Gerard Clarke; Olivia F O'Leary; John F Cryan; Timothy G Dinan
Journal: J Affect Disord Date: 2013-12-10 Impact factor: 4.839

4. Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers.

Authors: Marieke Niesters; Najmeh Khalili-Mahani; Christian Martini; Leon Aarts; Joop van Gerven; Mark A van Buchem; Albert Dahan; Serge Rombouts
Journal: Anesthesiology Date: 2012-10 Impact factor: 7.892

[Ketamine in the therapy of chronic pain and depression].

1. New use for an old drug: oral ketamine for treatment-resistant depression.

2. Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial.

Review 3. A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.

4. Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers.

5. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement.

6. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression.

7. Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study.

8. Ketamine-associated bladder dysfunction.

Review 9. Ketamine: Current applications in anesthesia, pain, and critical care.

10. Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series.