| Literature DB >> 30980167 |
Christian Muschitz1,2, Alexandra Kautzky-Willer3, Martina Rauner4, Yvonne Winhöfer-Stöckl3, Judith Haschka5.
Abstract
Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. The identification and management of fracture risk in these patients remains challenging. This manuscript explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated areal bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (FRAX) in these patients. It further reviews the impact of diabetes drugs on bone tissue as well as the efficacy of osteoporosis treatments in this population. An algorithm for the identification and management of diabetic patients at increased fracture risk is proposed.Entities:
Keywords: Diabetes; Diabetes-related bone disease; Fracture; Medication; Osteoporosis
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Year: 2019 PMID: 30980167 DOI: 10.1007/s00508-019-1462-0
Source DB: PubMed Journal: Wien Klin Wochenschr ISSN: 0043-5325 Impact factor: 1.704