Literature DB >> 30979349

Learning Moral Graphs in Construction of High-Dimensional Bayesian Networks for Mixed Data.

Suwa Xu1, Bochao Jia2, Faming Liang3.   

Abstract

Bayesian networks have been widely used in many scientific fields for describing the conditional independence relationships for a large set of random variables. This letter proposes a novel algorithm, the so-called p-learning algorithm, for learning moral graphs for high-dimensional Bayesian networks. The moral graph is a Markov network representation of the Bayesian network and also the key to construction of the Bayesian network for constraint-based algorithms. The consistency of the p-learning algorithm is justified under the small-n, large-p scenario. The numerical results indicate that the p-learning algorithm significantly outperforms the existing ones, such as the PC, grow-shrink, incremental association, semi-interleaved hiton, hill-climbing, and max-min hill-climbing. Under the sparsity assumption, the p-learning algorithm has a computational complexity of O(p2) even in the worst case, while the existing algorithms have a computational complexity of O(p3) in the worst case.

Entities:  

Year:  2019        PMID: 30979349      PMCID: PMC6874850          DOI: 10.1162/neco_a_01190

Source DB:  PubMed          Journal:  Neural Comput        ISSN: 0899-7667            Impact factor:   2.026


  13 in total

1.  Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.

Authors:  A K Virmani; A Rathi; U G Sathyanarayana; A Padar; C X Huang; H T Cunnigham; A J Farinas; S Milchgrub; D M Euhus; M Gilcrease; J Herman; J D Minna; A F Gazdar
Journal:  Clin Cancer Res       Date:  2001-07       Impact factor: 12.531

2.  Sparse inverse covariance estimation with the graphical lasso.

Authors:  Jerome Friedman; Trevor Hastie; Robert Tibshirani
Journal:  Biostatistics       Date:  2007-12-12       Impact factor: 5.899

3.  Efficient Markov Blanket Discovery and Its Application.

Authors:  Tian Gao; Qiang Ji
Journal:  IEEE Trans Cybern       Date:  2016-03-24       Impact factor: 11.448

4.  Learning gene regulatory networks from next generation sequencing data.

Authors:  Bochao Jia; Suwa Xu; Guanghua Xiao; Vishal Lamba; Faming Liang
Journal:  Biometrics       Date:  2017-03-10       Impact factor: 2.571

5.  Learning the Structure of Mixed Graphical Models.

Authors:  Jason D Lee; Trevor J Hastie
Journal:  J Comput Graph Stat       Date:  2015-01-01       Impact factor: 2.302

6.  PenPC: A two-step approach to estimate the skeletons of high-dimensional directed acyclic graphs.

Authors:  Min Jin Ha; Wei Sun; Jichun Xie
Journal:  Biometrics       Date:  2015-09-25       Impact factor: 2.571

7.  CGBayesNets: conditional Gaussian Bayesian network learning and inference with mixed discrete and continuous data.

Authors:  Michael J McGeachie; Hsun-Hsien Chang; Scott T Weiss
Journal:  PLoS Comput Biol       Date:  2014-06-12       Impact factor: 4.475

8.  Integrative network analysis of TCGA data for ovarian cancer.

Authors:  Qingyang Zhang; Joanna E Burdette; Ji-Ping Wang
Journal:  BMC Syst Biol       Date:  2014-12-31

9.  Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers.

Authors:  Ricardo A Verdugo; Tanja Zeller; Maxime Rotival; Philipp S Wild; Thomas Münzel; Karl J Lackner; Henri Weidmann; Ewa Ninio; David-Alexandre Trégouët; François Cambien; Stefan Blankenberg; Laurence Tiret
Journal:  PLoS One       Date:  2013-01-23       Impact factor: 3.240

10.  PIK3R1 underexpression is an independent prognostic marker in breast cancer.

Authors:  Magdalena Cizkova; Sophie Vacher; Didier Meseure; Martine Trassard; Aurélie Susini; Dana Mlcuchova; Celine Callens; Etienne Rouleau; Frederique Spyratos; Rosette Lidereau; Ivan Bièche
Journal:  BMC Cancer       Date:  2013-11-14       Impact factor: 4.430

View more
  3 in total

1.  Markov Neighborhood Regression for High-Dimensional Inference.

Authors:  Faming Liang; Jingnan Xue; Bochao Jia
Journal:  J Am Stat Assoc       Date:  2020-10-28       Impact factor: 4.369

2.  Fast hybrid Bayesian integrative learning of multiple gene regulatory networks for type 1 diabetes.

Authors:  Bochao Jia; Faming Liang
Journal:  Biostatistics       Date:  2021-04-10       Impact factor: 5.279

3.  Markov neighborhood regression for statistical inference of high-dimensional generalized linear models.

Authors:  Lizhe Sun; Faming Liang
Journal:  Stat Med       Date:  2022-06-10       Impact factor: 2.497

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.