Karen Curtin1,2,3, Lauren H Theilen4, Alison Fraser2, Ken R Smith2,5, Michael W Varner4, Gregory S Hageman3. 1. a Department of Internal Medicine , University of Utah School of Medicine , Salt Lake City , USA. 2. b Pedigree and Population Resource, Huntsman Cancer Institute , University of Utah , Salt Lake City , USA. 3. c Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Steele Center for Translational Medicine , University of Utah , Salt Lake City , USA. 4. d Department of Obstetrics/Gynecology , University of Utah School of Medicine , Salt Lake City , USA. 5. e Family Studies & Population Sciences , University of Utah , Salt Lake City , USA.
Abstract
Background: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD). Methods: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Risk of CNV AMD was estimated using Cox models. Findings: Women with HDP exhibited an 80% higher risk for early CNV AMD (age < 70 y; 95%CI 1.23-2.58). Conclusion: Our findings may have implications forearlier CNV AMD screening and detection.
Background: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD). Methods: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Risk of CNV AMD was estimated using Cox models. Findings: Women with HDP exhibited an 80% higher risk for early CNV AMD (age < 70 y; 95%CI 1.23-2.58). Conclusion: Our findings may have implications forearlier CNV AMD screening and detection.
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