Literature DB >> 30977662

Direct Access to Alkylideneoxindoles via Axially Enantioselective Knoevenagel Condensation.

Simone Crotti1, Nicola Di Iorio1, Chiara Artusi1, Andrea Mazzanti1, Paolo Righi1, Giorgio Bencivenni1.   

Abstract

The organocatalytic axially enantioselective Knoevenagel condensation between prochiral cyclohexanones and oxindoles is presented. The reaction, promoted by a primary amine, proceeded smoothly and furnished unprecedented examples of novel cyclohexylidene oxindoles displaying axial chirality.

Entities:  

Year:  2019        PMID： 30977662     DOI： 10.1021/acs.orglett.9b00505

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones.

Authors:  Yu-Hao Zhou; Yu-Zu Zhang; Zhu-Lian Wu; Tian Cai; Wei Wen; Qi-Xiang Guo
Journal:  Molecules       Date:  2020-02-03       Impact factor: 4.411

2.  The transient-chelating-group-controlled stereoselective Rh(i)-catalyzed silylative aminocarbonylation of 2-alkynylanilines: access to (Z)-3-(silylmethylene)indolin-2-ones.

Authors:  Ya-Fei Han; Gui-Fen Lv; Yang Li; Li-Jun Wu; Xuan-Hui Ouyang; Jin-Heng Li
Journal:  Chem Sci       Date:  2022-07-27       Impact factor: 9.969

3.  Rhodanine-based Knoevenagel reaction and ring-opening polymerization for efficiently constructing multicyclic polymers.

Authors:  Ze Zhang; Xuan Nie; Fei Wang; Guang Chen; Wei-Qiang Huang; Lei Xia; Wen-Jian Zhang; Zong-Yao Hao; Chun-Yan Hong; Long-Hai Wang; Ye-Zi You
Journal:  Nat Commun       Date:  2020-07-21       Impact factor: 14.919
  3 in total

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