Rodrigo M Forti1, Christopher G Favilla2, Jeffrey M Cochran3, Wesley B Baker4, John A Detre5, Scott E Kasner2, Michael T Mullen2, Steven R Messé2, W Andrew Kofke6, Ramani Balu2, David Kung7, Bryan A Pukenas7, Neda I Sedora-Roman8, Robert W Hurst7, Omar A Choudhri9, Rickson C Mesquita10, Arjun G Yodh3. 1. Institute of Physics, University of Campinas, Campinas, SP, Brazil; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, SP, Brazil; Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: rforti@ifi.unicamp.br. 2. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania. 3. Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania. 4. Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. 5. Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania. 6. Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania. 7. Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania. 8. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania. 9. Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania. 10. Institute of Physics, University of Campinas, Campinas, SP, Brazil; Brazilian Institute of Neuroscience and Neurotechnology, Campinas, SP, Brazil.
Abstract
INTRODUCTION: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular "snapshot." Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcranial monitoring of cerebral microvasculature. METHODS: Here, we use a combined DCS/DOS system to monitor frontal lobe hemodynamic changes during endovascular treatment of 2 patients with ischemic stroke due to internal carotid artery (ICA) occlusions. RESULTS AND DISCUSSION: The monitoring instrument identified a recanalization-induced increase in ipsilateral cerebral blood flow (CBF) with little or no concurrent change in contralateral CBF and extracerebral blood flow. The results suggest that diffuse optical monitoring is sensitive to intracerebral hemodynamics in patients with ICA occlusion and can measure microvascular responses to mechanical thrombectomy.
INTRODUCTION: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular "snapshot." Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcranial monitoring of cerebral microvasculature. METHODS: Here, we use a combined DCS/DOS system to monitor frontal lobe hemodynamic changes during endovascular treatment of 2 patients with ischemic stroke due to internal carotid artery (ICA) occlusions. RESULTS AND DISCUSSION: The monitoring instrument identified a recanalization-induced increase in ipsilateral cerebral blood flow (CBF) with little or no concurrent change in contralateral CBF and extracerebral blood flow. The results suggest that diffuse optical monitoring is sensitive to intracerebral hemodynamics in patients with ICA occlusion and can measure microvascular responses to mechanical thrombectomy.
Authors: Turgut Durduran; Guoqiang Yu; Mark G Burnett; John A Detre; Joel H Greenberg; Jiongjiong Wang; Chao Zhou; Arjun G Yodh Journal: Opt Lett Date: 2004-08-01 Impact factor: 3.776
Authors: Hasan Ayaz; Wesley B Baker; Giles Blaney; David A Boas; Heather Bortfeld; Kenneth Brady; Joshua Brake; Sabrina Brigadoi; Erin M Buckley; Stefan A Carp; Robert J Cooper; Kyle R Cowdrick; Joseph P Culver; Ippeita Dan; Hamid Dehghani; Anna Devor; Turgut Durduran; Adam T Eggebrecht; Lauren L Emberson; Qianqian Fang; Sergio Fantini; Maria Angela Franceschini; Jonas B Fischer; Judit Gervain; Joy Hirsch; Keum-Shik Hong; Roarke Horstmeyer; Jana M Kainerstorfer; Tiffany S Ko; Daniel J Licht; Adam Liebert; Robert Luke; Jennifer M Lynch; Jaume Mesquida; Rickson C Mesquita; Noman Naseer; Sergio L Novi; Felipe Orihuela-Espina; Thomas D O'Sullivan; Darcy S Peterka; Antonio Pifferi; Luca Pollonini; Angelo Sassaroli; João Ricardo Sato; Felix Scholkmann; Lorenzo Spinelli; Vivek J Srinivasan; Keith St Lawrence; Ilias Tachtsidis; Yunjie Tong; Alessandro Torricelli; Tara Urner; Heidrun Wabnitz; Martin Wolf; Ursula Wolf; Shiqi Xu; Changhuei Yang; Arjun G Yodh; Meryem A Yücel; Wenjun Zhou Journal: Neurophotonics Date: 2022-08-30 Impact factor: 4.212
Authors: Alistair Lewis; Rodrigo M Forti; Oladunni Alomaja; Clementina Mesaros; Sarah Piel; John C Greenwood; Fatima M Talebi; Constantine D Mavroudis; Matthew Kelly; Shih-Han Kao; Frances S Shofer; Johannes K Ehinger; Todd J Kilbaugh; Wesley B Baker; David H Jang Journal: J Med Toxicol Date: 2022-04-28
Authors: Alec Lafontant; Elizabeth Mahanna Gabrielli; Karla Bergonzi; Rodrigo M Forti; Tiffany S Ko; Ronak M Shah; Jeffrey S Arkles; Daniel J Licht; Arjun G Yodh; W Andrew Kofke; Brian R White; Wesley B Baker Journal: Neurophotonics Date: 2022-08-25 Impact factor: 4.212
Authors: Rodrigo M Forti; Marilise Katsurayama; Julien Menko; Lenise Valler; Andres Quiroga; Antonio L E Falcão; Li M Li; Rickson C Mesquita Journal: Front Med (Lausanne) Date: 2020-04-28