| Literature DB >> 3097318 |
J J Ares, P F Kador, D D Miller.
Abstract
5-Isothiocyanatoalrestatin (1b) and 5-azidoalrestatin (1c) were prepared synthetically and examined as potential affinity and photoaffinity inhibitors of rat lens aldose reductase. Both compound 1b and 1c under appropriate conditions at 10(-4) M produced a 70% irreversible inactivation of aldose reductase within 1 min. The enzyme could, in part, be protected by preincubation with sorbinil 2, a known potent inhibitor of aldose reductase.Entities:
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Year: 1986 PMID： 3097318 DOI： 10.1021/jm00161a040
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446