Literature DB >> 30972158

Human umbilical cord mesenchymal stem cells and exosomes: bioactive ways of tissue injury repair.

Siqi Yin1, Cheng Ji1, Peipei Wu1, Can Jin1, Hui Qian1.   

Abstract

Mesenchymal stem cells (MSCs) can be recruited to damaged tissues directly for regeneration. Exosomes, acting as an important ingredient of MSCs-involved intercellular communication through paracrine actions, also play significant roles in tissue damage repair and have a prospect of potential clinical application. It is generally recognized that MSC-derived exosomes (MSC-exosomes) enhance tissue regeneration and repair through reducing inflammatory responses, promoting proliferation, inhibiting apoptosis and facilitating angiogenesis. This review summarizes the positive effects of human umbilical cord mesenchymal stem cells (hucMSCs) and hucMSC-derived exosomes (hucMSC-exosomes) on tissue damage and the specific mechanisms of repair action.

Entities:  

Keywords:  HucMSC; exosomes; tissue injury repair

Year:  2019        PMID： 30972158      PMCID： PMC6456565     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  28 in total

1.  Large-Scale Expansion of Umbilical Cord Mesenchymal Stem Cells with Microcarrier Tablets in Bioreactor.

Authors:  Huanye Xu; Zhongxiao Cong; Yuanyuan Zhang; Wei Liu; Xiaojun Yan; Yanan Du
Journal:  Methods Mol Biol       Date:  2022

2.  Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.

Authors:  Hao Zhou; Xun Shen; Chen Yan; Wu Xiong; Zemeng Ma; Zhenggang Tan; Jinwen Wang; Yao Li; Jiuxiang Liu; Ao Duan; Feng Liu
Journal:  Stem Cell Res Ther       Date:  2022-07-16       Impact factor: 8.079

3.  Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use.

Authors:  Renato M S Cardoso; Silvia C Rodrigues; Claudia F Gomes; Filipe V Duarte; Maryse Romao; Ermelindo C Leal; Patricia C Freire; Ricardo Neves; Joana Simões-Correia
Journal:  Stem Cells Transl Med       Date:  2021-02-12       Impact factor: 6.940

Review 4.  Exosomal circRNAs: biogenesis, effect and application in human diseases.

Authors:  Yangxia Wang; Jinbo Liu; Junfen Ma; Ting Sun; Quanbo Zhou; Weiwei Wang; Guixian Wang; Pingjun Wu; Haijiang Wang; Li Jiang; Weitang Yuan; Zhenqiang Sun; Liang Ming
Journal:  Mol Cancer       Date:  2019-07-05       Impact factor: 27.401

5.  Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis.

Authors:  Lan Zhou; Ming Zong; Qiunong Guan; Gerald da Roza; Hao Wang; Hualin Qi; Caigan Du
Journal:  Stem Cells Int       Date:  2019-09-16       Impact factor: 5.443

6.  Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice.

Authors:  Stella Chin-Shaw Tsai; Kuender D Yang; Kuang-Hsi Chang; Frank Cheau-Feng Lin; Ruey-Hwang Chou; Min-Chih Li; Ching-Chang Cheng; Chien-Yu Kao; Chie-Pein Chen; Hung-Ching Lin; Yi-Chao Hsu
Journal:  Int J Mol Sci       Date:  2021-06-22       Impact factor: 5.923

Review 7.  Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses.

Authors:  Qian Hu; Christopher J Lyon; Jesse K Fletcher; Wenfu Tang; Meihua Wan; Tony Y Hu
Journal:  Acta Pharm Sin B       Date:  2020-12-19       Impact factor: 11.413

8.  Comparison of mesenchymal stromal cells from peritoneal dialysis effluent with those from umbilical cords: characteristics and therapeutic effects on chronic peritoneal dialysis in uremic rats.

Authors:  Yangchun Du; Ming Zong; Qiunong Guan; Zhongli Huang; Lan Zhou; Jing Cai; Gerald da Roza; Hao Wang; Hualin Qi; Yiping Lu; Caigan Du
Journal:  Stem Cell Res Ther       Date:  2021-07-13       Impact factor: 6.832

9.  Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway.

Authors:  Lingying Liu; Huinan Yin; Xingxia Hao; Huifeng Song; Jiake Chai; Hongjie Duan; Yang Chang; Longlong Yang; Yushou Wu; Shaofang Han; Xiaoteng Wang; Xiaotong Yue; Yunfei Chi; Wei Liu; Qiong Wang; Hongyu Wang; Hailiang Bai; Xiuxiu Shi; Shaozeng Li
Journal:  iScience       Date:  2020-07-18

10.  Proteomic Analysis of Exosomes from Adipose-Derived Mesenchymal Stem Cells: A Novel Therapeutic Strategy for Tissue Injury.

Authors:  Xin Xing; Shuang Han; Gu Cheng; Yifeng Ni; Zhi Li; Zubing Li
Journal:  Biomed Res Int       Date:  2020-03-03       Impact factor: 3.411
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