Literature DB >> 30972157

Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology.

Jiayu Song1,2,3, Jing Yu1,2,3, Gabriella Wenda Prayogo4, Weidong Cao1,2,3, Yimei Wu1,2, Zhanjun Jia1,2,3, Aihua Zhang1,2,3.   

Abstract

Kidney injury molecule 1 (KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion. It is also named as HAVCR1 (Hepatitis A virus cellular receptor 1) or TIM1 (T-cell immunoglobulin mucin receptor 1), and is expressed in the kidney, liver, and spleen. KIM-1 plays different roles via various molecular targets in immune diseases and kidney injury. KIM-1 is involved in HAV infections, autoimmunity, immune tolerance, and atopic diseases. The urinary KIM-1 level is closely related to its tissue level, and correspondingly related to kidney tissue damage. KIM-1 is not only an early biomarker of acute kidney injury (AKI), but also has a potential role in predicting the long-term renal outcome. In this review, we provide a summary of KIM-1's activities, focusing on the latest studies concerning the important roles of KIM-1 in the immune system and kidney diseases.

Entities:  

Keywords:  KIM-1; acute kidney injury; chronic kidney disease; immune; kidney diseases

Year:  2019        PMID： 30972157      PMCID： PMC6456506     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  32 in total

Review 1.  Antibody-Drug Conjugates in Uro-Oncology.

Authors:  Dawid Sigorski; Paweł Różanowski; Ewa Iżycka-Świeszewska; Katarzyna Wiktorska
Journal:  Target Oncol       Date:  2022-05-14       Impact factor: 4.864

Review 2.  The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft.

Authors:  Paul Luchian Aldea; Andreea Liana Rachisan; Bogdan Ioan Stanciu; Andrei Picos; Alina Monica Picos; Dan Ioan Delean; Ramona Stroescu; Magdalena Iuliana Starcea; Cristina Maria Borzan; Florin Ioan Elec
Journal:  Front Pediatr       Date:  2022-06-03       Impact factor: 3.569

3.  Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study.

Authors:  Ian E McCoy; Jesse Y Hsu; Joseph V Bonventre; Chirag R Parikh; Alan S Go; Kathleen D Liu; Ana C Ricardo; Anand Srivastava; Debbie L Cohen; Jiang He; Jing Chen; Panduranga S Rao; Chi-Yuan Hsu
Journal:  J Am Soc Nephrol       Date:  2022-03-16       Impact factor: 14.978

4.  Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease.

Authors:  Jennifer R Charlton; Weizhen Tan; Ghaleb Daouk; Lisa Teot; Seymour Rosen; Kevin M Bennett; Aleksandra Cwiek; Sejin Nam; Francesco Emma; François Jouret; João Paulo Oliveira; Lisbeth Tranebjærg; Carina Frykholm; Shrikant Mane; Friedhelm Hildebrandt; Tarak Srivastava; Tina Storm; Erik Ilsø Christensen; Rikke Nielsen
Journal:  Am J Physiol Renal Physiol       Date:  2020-10-26

5.  Anti-Oxidant and Anti-Inflammatory Effects of Lipopolysaccharide from Rhodobacter sphaeroides against Ethanol-Induced Liver and Kidney Toxicity in Experimental Rats.

Authors:  Eman T Mehanna; Al-Shimaa A Ali; Fatma El-Shaarawy; Noha M Mesbah; Dina M Abo-Elmatty; Nora M Aborehab
Journal:  Molecules       Date:  2021-12-08       Impact factor: 4.411

6.  Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction.

Authors:  Zhendong Feng; Han Xue Jiang; Huiyang Chen; Yu Ning Liu; Yahui Wang; Rui Bing Yang; Xueting Han; Chen Hui Xia; Ze Bing Zhu; Hongcai Shang; Aiming Wu; Wei Jing Liu
Journal:  Cardiol Res Pract       Date:  2020-06-20       Impact factor: 1.990

7.  Exposure to Iron Oxide Nanoparticles Coated with Phospholipid-Based Polymeric Micelles Induces Renal Transitory Biochemical and Histopathological Changes in Mice.

Authors:  Mihaela Balas; Ioana Mihaela Popescu Din; Anca Hermenean; Ludmila Otilia Cinteza; Anca Dinischiotu
Journal:  Materials (Basel)       Date:  2021-05-17       Impact factor: 3.623

8.  Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling.

Authors:  Qiuhua Zhang; Liang Wang; Mian Wu; Xiaobin Liu; Yushan Zhu; Jin Zhu; Changying Xing
Journal:  Mol Med Rep       Date:  2021-06-29       Impact factor: 2.952

9.  TIM-1 As a Signal Receptor Triggers Dengue Virus-Induced Autophagy.

Authors:  Li-Wei Chu; Chia-Jui Yang; Kuan-Jen Peng; Pei-Ling Chen; Shuu-Jiun Wang; Yueh-Hsin Ping
Journal:  Int J Mol Sci       Date:  2019-10-02       Impact factor: 5.923

10.  The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study.

Authors:  Justyna Wajda; Paulina Dumnicka; Witold Kolber; Mateusz Sporek; Barbara Maziarz; Piotr Ceranowicz; Marek Kuźniewski; Beata Kuśnierz-Cabala
Journal:  J Clin Med       Date:  2020-05-13       Impact factor: 4.241
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