Literature DB >> 3097061

Abnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals.

S Gupta.   

Abstract

Peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), asymptomatic homosexuals, and healthy heterosexuals were analyzed for the proportions and numbers of Leu 7+ cells and double-labeled Leu 2+7+ cells and for the natural killer functions. A significant increase in the proportions and numbers of Leu 7+ cells was observed in patients with AIDS and ARC and in asymptomatic homosexuals compared to healthy heterosexual men. The proportions of Leu 2+7+ cells were significantly increased in AIDS, ARC, and asymptomatic homosexuals, whereas the numbers were increased in asymptomatic homosexuals and ARC but not in AIDS compared to heterosexual controls. A significant increase in the number of Leu 2+7+ cells was observed in AIDS with Kaposi's sarcoma but not in AIDS with opportunistic infections. The natural killer function was significantly depressed in patients with AIDS and ARC and in asymptomatic homosexuals. These data suggest that the quantitative abnormalities of Leu 2+7+ cells appear early during the evolution of immunologic changes in HTLV III/LAV infection.

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Year:  1986        PMID： 3097061     DOI： 10.1007/bf00915256

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  25 in total

Review 1.  Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry.

Authors:  L L Lanier; E G Engleman; P Gatenby; G F Babcock; N L Warner; L A Herzenberg
Journal:  Immunol Rev       Date:  1983       Impact factor: 12.988

2.  NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.

Authors:  J A Brieva; S Targan; R H Stevens
Journal:  J Immunol       Date:  1984-02       Impact factor: 5.422

3.  Lymphocytic subsets in the acquired immunodeficiency syndrome.

Authors:  S Gupta; K Licorish; G Garthfield
Journal:  Ann Intern Med       Date:  1983-10       Impact factor: 25.391

4.  Autologous mixed lymphocyte reaction in man. XIV. Deficiency of the autologous mixed lymphocyte reaction in acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC). In vitro effect of purified interleukin-1 and interleukin-2.

Authors:  S Gupta; S Gillis; M Thornton; M Goldberg
Journal:  Clin Exp Immunol       Date:  1984-11       Impact factor: 4.330

Review 5.  Immunologic abnormalities in the acquired immunodeficiency syndrome.

Authors:  H C Lane; A S Fauci
Journal:  Annu Rev Immunol       Date:  1985       Impact factor: 28.527

Review 6.  Autologous mixed lymphocyte reaction in health and disease states in man.

Authors:  S Gupta
Journal:  Vox Sang       Date:  1983       Impact factor: 2.144

7.  Monocyte function in the acquired immune deficiency syndrome. Defective chemotaxis.

Authors:  P D Smith; K Ohura; H Masur; H C Lane; A S Fauci; S M Wahl
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

8.  Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome.

Authors:  A H Rook; H Masur; H C Lane; W Frederick; T Kasahara; A M Macher; J Y Djeu; J F Manischewitz; L Jackson; A S Fauci; G V Quinnan
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808

9.  Expansion of a minor subpopulation of peripheral blood lymphocytes (T8+/Leu 7+) in patients with haemophilia.

Authors:  H W Ziegler-Heitbrock; W Schramm; D Stachel; H Rumpold; D Kraft; D Wernicke; K von der Helm; J Eberle; F Deinhardt; E P Rieber
Journal:  Clin Exp Immunol       Date:  1985-09       Impact factor: 4.330

10.  Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life.

Authors:  T Abo; C A Miller; G L Gartland; C M Balch
Journal:  J Exp Med       Date:  1983-01-01       Impact factor: 14.307
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  18 in total

1.  CD8 T lymphocyte subset markers and HIV infection.

Authors:  A G Bird; K C Watret
Journal:  Clin Exp Immunol       Date:  1992-12       Impact factor: 4.330

2.  Abnormal T cell receptor V gene usage in myasthenia gravis: prevalence and characterization of expanded T cell populations.

Authors:  B Y Xu; R Giscombe; A Söderlund; M Troye-Blomberg; R Pirskanen; A K Lefvert
Journal:  Clin Exp Immunol       Date:  1998-09       Impact factor: 4.330

3.  Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging.

Authors:  S E McNerlan; I M Rea; H D Alexander; T C Morris
Journal:  J Clin Immunol       Date:  1998-01       Impact factor: 8.317

4.  Preferential loss of Leu 8-, CD45R, HLA-DR+ CD8 cell subsets during in vitro culture of mononuclear cells from human immunodeficiency virus type I (HIV)-seropositive former blood donors.

Authors:  H E Prince; C D Czaplicki
Journal:  J Clin Immunol       Date:  1989-09       Impact factor: 8.317

5.  The small heat shock protein 27 is a key regulator of CD8+ CD57+ lymphocyte survival.

Authors:  Karen L Wood; Oliver H Voss; Qin Huang; Arti Parihar; Neeraj Mehta; Sanjay Batra; Andrea I Doseff
Journal:  J Immunol       Date:  2010-04-12       Impact factor: 5.422

6.  Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28- CD8+ T-cell population.

Authors:  M P Weekes; M R Wills; K Mynard; R Hicks; J G Sissons; A J Carmichael
Journal:  Immunology       Date:  1999-11       Impact factor: 7.397

7.  Emergence of non-major-histocompatibility-complex-restricted lytic CD8+ cells in the blood of nasopharyngeal carcinoma patients.

Authors:  M Lakhdar; H Thameur; M Maalej; F Ben Ayed; A Ladgham
Journal:  Cancer Immunol Immunother       Date:  1993-07       Impact factor: 6.968

8.  Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity.

Authors:  Emily M Eriksson; Jeffrey M Milush; Emily L Ho; Mariana D Batista; Sara J Holditch; Chris E Keh; Philip J Norris; Sheila M Keating; Steven G Deeks; Peter W Hunt; Jeffrey N Martin; Michael G Rosenberg; Frederick M Hecht; Douglas F Nixon
Journal:  Blood       Date:  2011-12-01       Impact factor: 22.113

9.  Subsets of CD8+, CD57+ cells in normal, healthy individuals: correlations with human cytomegalovirus (HCMV) carrier status, phenotypic and functional analyses.

Authors:  E C Wang; J Taylor-Wiedeman; P Perera; J Fisher; L K Borysiewicz
Journal:  Clin Exp Immunol       Date:  1993-11       Impact factor: 4.330

10.  Expanded T cell populations in patients with Wegener's granulomatosis: characteristics and correlates with disease activity.

Authors:  R Giscombe; S Nityanand; N Lewin; J Grunewald; A K Lefvert
Journal:  J Clin Immunol       Date:  1998-11       Impact factor: 8.317
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