[Expression profiles of microRNA related to atherosclerosis in patients with OSA].

Objective:Recent studies have demonstrated that obstructive sleep apnoea(OSA) may lead to atherosclerosis(AS), but the underlying mechanism remains unclear. MicroRNA(miRNA) may be involved in the gene regulation of AS and also in the occurrence and progression of OSA. The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA-127-3p and miRNA-365a-3p were upregulated in the OSA, OSA-AS, and AS groups; miRNA-134-5p was only upregulated in the AS group, miRNA-365a-3p in the OSA-AS group was higher than that in the OSA alone group. The circulating atherosclerosis related miRNAs, including miRNA-148a-5p, miRNA-378c, miRNA-127-3p, miRNA-134-5p and miRNA-365a-3p all correlated with the carotid intima media thickness.
Conclusion: Upregulation of miRNA-148a-5p, miRNA-365a-3p, miRNA-378c, miRNA-127-3p may be an early warning marker of atherosclerosis in OSA patients. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.