| Literature DB >> 30967367 |
Thomas E Witzig1, David Inwards1.
Abstract
Mantle cell lymphoma (MCL) is a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. MCL patients typically live for years but experience multiple relapses. Acalabrutinib is a novel second-generation oral Bruton tyrosine kinase inhibitor approved by the US Food and Drug Administration for relapsed MCL based on a clinical trial demonstrating an overall response rate of 81%. It provides a valuable new treatment option for MCL patients and is now being tested upfront.Entities:
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Year: 2019 PMID: 30967367 DOI: 10.1182/blood.2019852368
Source DB: PubMed Journal: Blood ISSN: 0006-4971 Impact factor: 22.113