| Literature DB >> 30965130 |
Ying Fu1, Pu Zhang1, Hui Nan2, Yiming Lu3, Jun Zhao1, Mengxiang Yang1, Qingcui Song4.
Abstract
LncRNA CASC11 is a recently identified oncogenic lncRNA in colorectal cancer. This study aimed to investigate the role of lncRNA CASC11 in small cell lung cancer (SCLC). In the present study, expression levels of CASC11 and TGF-β1 were found to be positively and significantly correlated with the percentage of CDD133+ cells of SCLC cell lines. Plasma CASC11 and TGF-β1 were upregulated and positively correlated in SCLC patients, but not in healthy controls. Upregulation of plasma CASC11 and TGF-β1 predicted poor survival of SCLC patients. Overexpression of CASC11 and TGF-β1 also resulted in the increased percentage of CDD133+ cells of SCLC cell lines, while TGF-β inhibitor attenuated the effects of CASC11 overexpression. CASC11 overexpression mediated the upregulation of TGF-β1 in SCLC cells, while treatment with exogenous TGF-β1 showed no significant effect on CASC11. Therefore, lncRNA CASC11 promotes TGF-β1, increases cancer cell stemness and predicts postoperative survival in SCLC.Entities:
Keywords: LncRNA CASC11; Small cell lung cancer; Stemness; Survival; TGF-β1
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Year: 2019 PMID： 30965130 DOI： 10.1016/j.gene.2019.04.019
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688