BACKGROUND: Guava has benefit phytochemicals that are important for skin-disorder treatment. Nevertheless, its efficacy against oily skin has never been reported. AIMS: The guava toner was developed and clinical evaluated. METHODS: The base toner was formulated, accelerated stability tested, and sensory-evaluated in 10 volunteers. The highest preference base was incorporated with guava extract, stability examined, and skin irritation assessed in 21 volunteers by a single application close patch test. Anti-sebum efficacy was split-face, randomized, single-blind placebo-controlled evaluated in 21 volunteers for 28 days and monitored by Sebutape® on forehead and nose. RESULTS: The stable toner base with the greatest preference (83.20 ± 1.85%) was incorporated with 3%, 4.5%, and 6% of guava extract. The toners were stable with none of skin irritation. The toner with 6% guava extract was selected for efficacy evaluation. Guava toner significantly reduced oiliness of forehead (13.10 ± 3.67%, P < 0.05) and nose (21.43 ± 3.21%, P < 0.001) better than the base toner. The activity on nose was significantly noted (10.72 ± 3.51%, P < 0.05) since the 3rd week of application. CONCLUSIONS: Anti-sebum guava toner was efficiently evidence approved and suitable for a daily application to improve the efficacy.
RCT Entities:
BACKGROUND:Guava has benefit phytochemicals that are important for skin-disorder treatment. Nevertheless, its efficacy against oily skin has never been reported. AIMS: The guava toner was developed and clinical evaluated. METHODS: The base toner was formulated, accelerated stability tested, and sensory-evaluated in 10 volunteers. The highest preference base was incorporated with guava extract, stability examined, and skin irritation assessed in 21 volunteers by a single application close patch test. Anti-sebum efficacy was split-face, randomized, single-blind placebo-controlled evaluated in 21 volunteers for 28 days and monitored by Sebutape® on forehead and nose. RESULTS: The stable toner base with the greatest preference (83.20 ± 1.85%) was incorporated with 3%, 4.5%, and 6% of guava extract. The toners were stable with none of skin irritation. The toner with 6% guava extract was selected for efficacy evaluation. Guava toner significantly reduced oiliness of forehead (13.10 ± 3.67%, P < 0.05) and nose (21.43 ± 3.21%, P < 0.001) better than the base toner. The activity on nose was significantly noted (10.72 ± 3.51%, P < 0.05) since the 3rd week of application. CONCLUSIONS: Anti-sebum guava toner was efficiently evidence approved and suitable for a daily application to improve the efficacy.
Authors: Abigail García-Villegas; Alejandro Rojas-García; María Del Carmen Villegas-Aguilar; Patricia Fernández-Moreno; Álvaro Fernández-Ochoa; María de la Luz Cádiz-Gurrea; David Arráez-Román; Antonio Segura-Carretero Journal: Antioxidants (Basel) Date: 2022-01-21