Literature DB >> 30963375

Two new alkaloids from Crinum asiaticum var. japonicum.

Yuta Endo1, Yu Sugiura1, Mariko Funasaki1, Hiroyuki Kagechika2, Masami Ishibashi3, Ayumi Ohsaki4.   

Abstract

A new crinine-type alkaloid crijaponine A (1), a new galanthamine-type alkaloid crijaponine B (2), and 11 known alkaloids-ungeremine (3), lycorine (4), 2-O-acetyllycorine (5), 1, 2-O-diacetyllycorine (6), (-)-crinine (7), 11-hydroxyvittatine (8), hamayne (9), (+)-epibuphanisine (10), crinamine (11), yemenine A (12), and epinorgalanthamine (13)-were isolated from the rhizome and fruits of Crinum asiaticum var. japonicum. The structural elucidation of the isolated compounds was performed by spectroscopic methods including 2D NMR. The isolated compounds were evaluated for cytotoxicity against HeLa and HL-60 cells lines and were tested for acetylcholinesterase inhibition activity.

Entities:  

Keywords:  Acetylcholinesterase inhibitory activity; Crinine alkaloid; Crinum asiaticum var. japonicum; Cytotoxicity; Galanthamine alkaloid

Mesh：

Substances：

Year:  2019        PMID： 30963375     DOI： 10.1007/s11418-019-01304-9

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  6 in total

1.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

2.  Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.

Authors:  Delphine Lamoral-Theys; Anna Andolfi; Gwendoline Van Goietsenoven; Alessio Cimmino; Benjamin Le Calvé; Nathalie Wauthoz; Véronique Mégalizzi; Thierry Gras; Céline Bruyère; Jacques Dubois; Véronique Mathieu; Alexander Kornienko; Robert Kiss; Antonio Evidente
Journal:  J Med Chem       Date:  2009-10-22       Impact factor: 7.446

3.  Phytochemical and biological investigation of Hymenocallis littoralis SALISB.

Authors:  Amina H Abou-Donia; Soad M Toaima; Hala M Hammoda; Eman Shawky; Eri Kinoshita; Hiromitsu Takayama
Journal:  Chem Biodivers       Date:  2008-02       Impact factor: 2.408

4.  New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.

Authors:  Osama Bashir Abdel-Halim; Toshio Morikawa; Shin Ando; Hisashi Matsuda; Masayuki Yoshikawa
Journal:  J Nat Prod       Date:  2004-07       Impact factor: 4.050

5.  A lanostane triterpenoid and three cholestane sterols from Tilia kiusiana.

Authors:  Marie Shimada; Masaaki Ozawa; Kojiro Iwamoto; Yoshiyasu Fukuyama; Akio Kishida; Ayumi Ohsaki
Journal:  Chem Pharm Bull (Tokyo)       Date:  2014       Impact factor: 1.645

6.  Total syntheses of (+/-)-crinine, (+/-)-crinamine, and (+/-)-6a-epi-crinamine via the regioselective synthesis and Diels-Alder reaction of 3-aryl-5-bromo-2-pyrone.

Authors:  Thanh Tam Nguyen; Jayhyok Chang; Eun-Ju Jung; Cheon-Gyu Cho
Journal:  J Org Chem       Date:  2008-07-16       Impact factor: 4.354
  6 in total
  3 in total

Review 1.  The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: 'Talented' Taxa from the Amaryllidaceae.

Authors:  Cynthia Amaning Danquah; Prince Amankwah Baffour Minkah; Theresa A Agana; Phanankosi Moyo; Michael Ofori; Peace Doe; Sibusiso Rali; Isaiah Osei Duah Junior; Kofi Bonsu Amankwah; Samuel Owusu Somuah; Isaac Newton Nugbemado; Vinesh J Maharaj; Sanjib Bhakta; Simon Gibbons
Journal:  Molecules       Date:  2022-07-13       Impact factor: 4.927

2.  Crinamine Induces Apoptosis and Inhibits Proliferation, Migration, and Angiogenesis in Cervical Cancer SiHa Cells.

Authors:  Phattharachanok Khumkhrong; Kitiya Piboonprai; Waraluck Chaichompoo; Wittaya Pimtong; Mattaka Khongkow; Katawut Namdee; Angkana Jantimaporn; Deanpen Japrung; Udom Asawapirom; Apichart Suksamrarn; Tawin Iempridee
Journal:  Biomolecules       Date:  2019-09-16

Review 3.  Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids.

Authors:  Seydou Ka; Manoj Koirala; Natacha Mérindol; Isabel Desgagné-Penix
Journal:  Molecules       Date:  2020-10-23       Impact factor: 4.411
  3 in total

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