Literature DB >> 30962345

Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community.

Anaïs Potron1,2,3, Didier Hocquet2,4,5, Pauline Triponney3, Patrick Plésiat6,2,3, Xavier Bertrand2,4, Benoit Valot2.   

Abstract

Nineteen Proteus mirabilis isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Whole-genome analysis revealed that all 19 isolates formed a cluster compared to 149 other P. mirabilis isolates. Because of its susceptibility to carbapenems, this clone may be misidentified as a penicillinase producer while it constitutes a reservoir of the OXA-23-encoding gene in the community.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  OXA-23; Proteus mirabiliszzm321990; carbapenemase; clonality; spread

Mesh:

Substances:

Year:  2019        PMID: 30962345      PMCID: PMC6535531          DOI: 10.1128/AAC.00191-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  17 in total

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Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

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