Vittorio Moraschini1, Daniel Costa Ferreira de Almeida2, Carlos Marcelo Figueredo3, Monica Diuana Calasans-Maia4. 1. Fluminense Federal University, Department of Periodontology, School of Dentistry, Salgado de Oliveira University, Rio de Janeiro, Brazil. Electronic address: Vitt.mf@gmail.com. 2. Department of Implantology, Brazilian Air Force, Odontoclínica de Aeronáutica Santos-Dumont, Rio de Janeiro, Brazil. 3. Department of Periodontology, Faculty of Dentistry and Oral Health, Griffith University, Queensland, Australia. 4. Department of Oral Surgery, School of Dentistry, Fluminense Federal University, Rio de Janeiro, Brazil.
Abstract
OBJECTIVES: Our aim was to conduct a systematic review (SR) of the literature assessing the role of human biomarkers in the diagnosis or prognostication of medication-related osteonecrosis of the jaws (MRONJ). STUDY DESIGN: An electronic search without date or language restriction was carried out in PubMed/MEDLINE, the Cochrane Central Register of Controlled Trials, Web of Science, and LILACS for publications until March 2018. In addition, a manual search in the gray literature was conducted. The search process was performed by 2 independent reviewing authors. Eligibility criteria included randomized and nonrandomized clinical trials, prospective or retrospective cohorts, case controls, and case series evaluating the association between biomarkers and MRONJ. The protocol of this SR was registered in PROSPERO under number CRD42018095886. RESULTS: The search and selection process yielded 19 studies (2 case series, 6 case-control studies, 9 prospective cohort studies, and 2 retrospective studies) published between 2008 and 2018. Twenty-four biomarkers collected from serum, saliva, and urine were investigated by these studies. Eleven biomarkers were possibly related to MRONJ; however, no consensus is observed in the literature with regard to the sensitivity and clinical effectiveness of these biomarkers. CONCLUSIONS: Although many biomarkers have been associated with MRONJ, the present SR found scarce clinical evidence supporting the use of these biomarkers for the diagnosis and prognosis of MRONJ.
OBJECTIVES: Our aim was to conduct a systematic review (SR) of the literature assessing the role of human biomarkers in the diagnosis or prognostication of medication-related osteonecrosis of the jaws (MRONJ). STUDY DESIGN: An electronic search without date or language restriction was carried out in PubMed/MEDLINE, the Cochrane Central Register of Controlled Trials, Web of Science, and LILACS for publications until March 2018. In addition, a manual search in the gray literature was conducted. The search process was performed by 2 independent reviewing authors. Eligibility criteria included randomized and nonrandomized clinical trials, prospective or retrospective cohorts, case controls, and case series evaluating the association between biomarkers and MRONJ. The protocol of this SR was registered in PROSPERO under number CRD42018095886. RESULTS: The search and selection process yielded 19 studies (2 case series, 6 case-control studies, 9 prospective cohort studies, and 2 retrospective studies) published between 2008 and 2018. Twenty-four biomarkers collected from serum, saliva, and urine were investigated by these studies. Eleven biomarkers were possibly related to MRONJ; however, no consensus is observed in the literature with regard to the sensitivity and clinical effectiveness of these biomarkers. CONCLUSIONS: Although many biomarkers have been associated with MRONJ, the present SR found scarce clinical evidence supporting the use of these biomarkers for the diagnosis and prognosis of MRONJ.
Authors: Ana Laura Soares; Sérgio Simon; Luiz Henrique Gebrim; Afonso Celso P Nazário; Marise Lazaretti-Castro Journal: Support Care Cancer Date: 2019-08-29 Impact factor: 3.603
Authors: Jeffrey W Chadwick; Howard C Tenenbaum; Chun-Xiang Sun; Robert E Wood; Michael Glogauer Journal: Sci Rep Date: 2020-10-27 Impact factor: 4.379