Hsu-Chih Huang1, Frank Cheau-Feng Lin2, Ming-Fang Wu3, Oswald Ndi Nfor4, Shu-Yi Hsu4, Chia-Chi Lung4, Chien-Chang Ho5, Chih-Yi Chen6, Yung-Po Liaw7. 1. Institute of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan. 2. School of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan. 3. School of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan; Divisions of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung City 402, Taiwan, ROC. 4. Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, 40201, Taiwan. 5. Department of Physical Education, Fu Jen Catholic University, New Taipei City, Taiwan. 6. Institute of Medicine, Chung Shan Medical University, Taichung City, 40201, Taiwan; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan. Electronic address: cshy1566@csh.org.tw. 7. Divisions of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung City 402, Taiwan, ROC; Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan. Electronic address: Liawyp@csmu.edu.tw.
Abstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world. Not much is known regarding the influence of non-smoking-related risk factors on COPD in Taiwan. We examined the relationship between exposure to particulate matter <2.5 μm (PM2.5) and COPD among nonsmokers in Taiwan. METHODS: This population-based study involved 3941 nonsmoking Taiwanese adults who were recruited in the Taiwan Biobank project between 2008 and 2015. Air pollution data between 2006 and 2011 were obtained from the air quality monitoring database (AQMD). COPD was the outcome of interest and was identified using the National health insurance Research Database (NHIRD). The data were analyzed using multiple logistic regression models. RESULTS: Compared with the lowest quartile (PM2.5 = 29.38), exposure to PM2.5 in the highest quartile (>38.98 μg/m3) was significantly associated with COPD (OR, 1.29; CI 1.01-1.65) after multivariate adjustments. However, exposures to concentrations of 32.07-38.98 μg/m3 (OR, 1.12 CI 0.88-1.44) and 29.38-32.07 μg/m3 (OR, 1.09 CI 0.84-1.41) showed positive but non-significant associations. However, the test for trend was significant (Ptrend = 0.043). The ORs for exposure to sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO) and NOx (nitrogen monoxide (NO were not significant. CONCLUSIONS: Based on our data, exposure to PM2.5 at concentrations greater than 38.98 μg/m3 increased susceptibility to COPD among Taiwanese nonsmokers. Combatting COPD would involve integrating tobacco control and pollution management strategies.
BACKGROUND:Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world. Not much is known regarding the influence of non-smoking-related risk factors on COPD in Taiwan. We examined the relationship between exposure to particulate matter <2.5 μm (PM2.5) and COPD among nonsmokers in Taiwan. METHODS: This population-based study involved 3941 nonsmoking Taiwanese adults who were recruited in the Taiwan Biobank project between 2008 and 2015. Air pollution data between 2006 and 2011 were obtained from the air quality monitoring database (AQMD). COPD was the outcome of interest and was identified using the National health insurance Research Database (NHIRD). The data were analyzed using multiple logistic regression models. RESULTS: Compared with the lowest quartile (PM2.5 = 29.38), exposure to PM2.5 in the highest quartile (>38.98 μg/m3) was significantly associated with COPD (OR, 1.29; CI 1.01-1.65) after multivariate adjustments. However, exposures to concentrations of 32.07-38.98 μg/m3 (OR, 1.12 CI 0.88-1.44) and 29.38-32.07 μg/m3 (OR, 1.09 CI 0.84-1.41) showed positive but non-significant associations. However, the test for trend was significant (Ptrend = 0.043). The ORs for exposure to sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO) and NOx (nitrogen monoxide (NO were not significant. CONCLUSIONS: Based on our data, exposure to PM2.5 at concentrations greater than 38.98 μg/m3 increased susceptibility to COPD among Taiwanese nonsmokers. Combatting COPD would involve integrating tobacco control and pollution management strategies.
Authors: Xerxes Seposo; Audrey Lynn A Arcilla; Jose Guillermo N De Guzman; Enrico Miguel S Dizon; Andrea Nova R Figuracion; Christina Micaela M Morales; Pauleena Katriona A Tugonon; Geminn Louis C Apostol Journal: Chronic Dis Transl Med Date: 2021-02-23