| Literature DB >> 30961478 |
Shuangshuang Zhang1, Yong Wang1, Jinsong Cheng1, Ning Huangfu1, Ruochi Zhao1, Zhenyu Xu1, Fuxing Zhang1, Wenyuan Zheng1, Dandan Zhang2.
Abstract
Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Uric acid; cardiovascular diseases; chronic kidney disease; gout; hyperuricaemia; metabolic syndrome.
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Year: 2019 PMID： 30961478 DOI： 10.2174/1381612825666190408122557
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116