Literature DB >> 30961363

Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity.

Thi Men Ngo1, Phuong Thao Tran2, Le Son Hoang3, Jeong-Hyung Lee2, Byung Sun Min3, Jeong Ah Kim1.   

Abstract

Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14-16) together with twelve known compounds (1, 2, 4-13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an IC50 value of 3.4 ± 1.2 μM.

Entities:  

Keywords:  Salvia miltiorrhiza; anti-inflammatory activity; diterpene alkaloid; nitric oxide production

Mesh：

Substances：

Year:  2019        PMID： 30961363     DOI： 10.1080/14786419.2019.1596098

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  3 in total

1.  Exploration on the Improvement of Cognitive Function and Inflammatory Response in Perimenopausal Patients with Mild Cognitive Impairment by Self-Prepared Ningshen Prescription.

Authors:  Wei Yang; Yumei Ye; Yan Cai; Guiyan Wang; Menghao Wang; Xiaodan Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2022-06-02       Impact factor: 2.650

2.  The mixture of Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge. extract produces analgesic and anti-inflammatory effects in a collagen-induced arthritis mouse model.

Authors:  Jing Hui Feng; Jeon Sub Jung; Seung Hwan Hwang; Soo Kyeong Lee; Sang Youn Lee; Youn Gil Kwak; Doo-Ho Kim; Chu-Youn Song; Min Jung Kim; Hong Won Suh; Sung Chan Kim; Soon Sung Lim
Journal:  Anim Cells Syst (Seoul)       Date:  2022-08-08       Impact factor: 2.398

3.  The Anti-Inflammatory and the Antinociceptive Effects of Mixed Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge Extract.

Authors:  Jing-Hui Feng; Hyun-Yong Kim; Su-Min Sim; Guang-Lei Zuo; Jeon-Sub Jung; Seung-Hwan Hwang; Youn-Gil Kwak; Min-Jung Kim; Jeong-Hun Jo; Sung-Chan Kim; Soon-Sung Lim; Hong-Won Suh
Journal:  Plants (Basel)       Date:  2021-06-17
  3 in total

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