Transient Ligand-Enabled Transition Metal-Catalyzed C-H Functionalization.

Transition metal-catalyzed C-H bond functionalization is among the most efficient and powerful strategies in synthetic organic chemistry to derivatize otherwise inert sites of organic molecules for the construction of C-C and C-heteroatom bonds. However, additional steps are often required to install the directing groups to realize selective C-H bond functionalization of the substrates. These tedious steps run counter to the step-economical nature of the C-H activation. In contrast, direct functionalization of the substrate by using transient ligands avoids the unnecessary steps for the pre-functionalization of the substrates. This Minireview provides a short overview of the major progress made in this field for C-H functionalization at sp2 and sp3 carbon centers with different transient working modes, including covalent, hydrogen, and ionic bonds.