DYNAMICS OF INDICES OF OXIDATIVE STRESS IN PATIENTS WITH THYROID GLAND SURGERY DEPENDING ON ITS FUNCTIONAL ACTIVITY.

Hormonal dysfunction of the thyroid gland causes disorder of all kinds of metabolism. Both hypothyroidism, and hyperthyroidism are the causes of imbalance in prooxidant-antioxidant system with the development of pathological process named "oxidative stress". Objective - study of oxidative stress in patients who underwent thyroid gland operation depending on its functional activity and the presence of autoimmune thyroiditis. The intensity of lipid peroxidation was examined by concentration of diene conjugates and malondialdehyde, and the activity of antioxidant system by the level of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase of red blood cells. It was established that the activity level of the lipid peroxidation system and the activity of antioxidant defense enzymes have their specific characteristics depending on the various functional states of the thyroid gland, as well as on the presence or absence of autoimmune component in the structure of thyroid pathology. All changes occurring in patients with this pathology accompanied by hormonal imbalance and autoimmune thyroiditis, lead to development of chronic nonspecific metabolic endogenous intoxication.