Literature DB >> 30956477

Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For?

Vinaya Maiskar1, Sushama Surve1.   

Abstract

Progesterone supplementation is a routine practice after intrauterine insemination and IVF-ET procedures. Progesterone is indicated in patients of PCOS and cervical incompetence. It also helps in prevention of recurrent unexplained miscarriages. Effect of a high dose of progesterone supplementation in causing earlier onset of Intrahepatic cholestasis of pregnancy (ICP) merits further focussed investigation.

Entities:  

Keywords:  3β-Sulfated progesterone metabolites; Intrahepatic cholestasis of pregnancy (ICP); Ursodeoxycholic acid (UDCA)

Year:  2018        PMID： 30956477      PMCID： PMC6430258          DOI： 10.1007/s13224-018-1174-9

Source DB:  PubMed          Journal:  J Obstet Gynaecol India        ISSN： 0975-6434


  5 in total

Review 1.  Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials.

Authors:  Gabriele Saccone; Corina Schoen; Jason M Franasiak; Richard T Scott; Vincenzo Berghella
Journal:  Fertil Steril       Date:  2016-11-22       Impact factor: 7.329

Review 2.  The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy.

Authors:  A Pařízek; M Dušková; L Vítek; M Šrámková; M Hill; K Adamcová; P Šimják; A Černý; Z Kordová; H Vráblíková; B Boudová; M Koucký; K Malíčková; L Stárka
Journal:  Physiol Res       Date:  2015       Impact factor: 1.881

3.  Co-morbidity of cervical incompetence with polycystic ovarian syndrome (PCOS) negatively impacts prognosis: A retrospective analysis of 178 patients.

Authors:  Yongqing Wang; Xunke Gu; Liyuan Tao; Yangyu Zhao
Journal:  BMC Pregnancy Childbirth       Date:  2016-10-12       Impact factor: 3.007

4.  Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype.

Authors:  Shadi Abu-Hayyeh; Georgia Papacleovoulou; Anita Lövgren-Sandblom; Mehreen Tahir; Olayiwola Oduwole; Nurul Akmal Jamaludin; Sabiha Ravat; Vanya Nikolova; Jenny Chambers; Clare Selden; Myrddin Rees; Hanns-Ulrich Marschall; Malcolm G Parker; Catherine Williamson
Journal:  Hepatology       Date:  2013-01-08       Impact factor: 17.425

5.  Intra-hepatic Cholestasis of Pregnancy: A Comprehensive Review.

Authors:  Sangita Ghosh; Soumik Chaudhuri
Journal:  Indian J Dermatol       Date:  2013-07       Impact factor: 1.494
  5 in total

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