Brandon J Patterson1, Debora A Rausch2, Debra E Irwin3, Michael Liang4, Songkai Yan5, Barbara P Yawn6. 1. U.S. Health Outcomes & Epidemiology, GSK, Philadelphia, PA. Electronic address: brandon.j.patterson@gsk.com. 2. Medical Affairs, GSK, Philadelphia, PA. 3. Outcomes Research, Truven Health Analytics, an IBM Company, Durham, NC. 4. Outcomes Research, Truven Health Analytics, an IBM Company, Cambridge, MA. 5. U.S. Health Outcomes & Epidemiology, GSK, Philadelphia, PA. 6. Department of Family Medicine and Community Health, University of Minnesota, Minneapolis.
Abstract
OBJECTIVE: To estimate the risk of transient ischemic attack (TIA), stroke, and myocardial infarction in periods covering 4 weeks before to 52 weeks after herpes zoster (HZ) diagnosis in US adults. PATIENTS AND METHODS: This retrospective study (GSK study identifier: HO-15-15771) with matched cohorts used the Truven Health MarketScan Commercial and Medicare claims data set linked with obesity and smoking status information. Patients 18 years and older at the date of HZ diagnosis and 1-year pre- and post-HZ diagnosis continuous insurance enrollment (from January 1, 2007, through December 31, 2014) were propensity score matched to controls in terms of demographic characteristics, risk factors for vascular events, other comorbid disorders, general health, obesity, and smoking status. A post hoc sensitivity analysis was performed not matching for obesity and smoking status information. Adjusted incidence rate ratios (IRRs) were estimated using multivariate Poisson models during an aggregate period (1-month before and after the index date). RESULTS: A total of 23,339 patients with HZ were matched to 46,378 controls (mean age, 56 years; 45,173 [65%] women). During the aggregate period, patients with HZ were statistically significantly more likely to suffer a TIA: IRRs for all patients and patients aged 18 to 49 years were 1.56 (95% confidence interval [CI], 1.13-2.15) and 5.12 (95% CI, 1.37-19.10), respectively (P<.05); the respective IRRs for stroke were 1.40 (95% CI, 0.93-2.11) and 8.12 (95% CI, 0.93-71.27). In the sensitivity analysis, IRRs for TIA and stroke were statistically significantly increased regardless of age. CONCLUSION: Herpes zoster was associated with an increased risk of composite events, TIA, and stroke in adults in the period around diagnosis. More research on the HZ and vascular risk association is needed. GSK STUDY IDENTIFIER: HO-15-15771.
OBJECTIVE: To estimate the risk of transient ischemic attack (TIA), stroke, and myocardial infarction in periods covering 4 weeks before to 52 weeks after herpes zoster (HZ) diagnosis in US adults. PATIENTS AND METHODS: This retrospective study (GSK study identifier: HO-15-15771) with matched cohorts used the Truven Health MarketScan Commercial and Medicare claims data set linked with obesity and smoking status information. Patients 18 years and older at the date of HZ diagnosis and 1-year pre- and post-HZ diagnosis continuous insurance enrollment (from January 1, 2007, through December 31, 2014) were propensity score matched to controls in terms of demographic characteristics, risk factors for vascular events, other comorbid disorders, general health, obesity, and smoking status. A post hoc sensitivity analysis was performed not matching for obesity and smoking status information. Adjusted incidence rate ratios (IRRs) were estimated using multivariate Poisson models during an aggregate period (1-month before and after the index date). RESULTS: A total of 23,339 patients with HZ were matched to 46,378 controls (mean age, 56 years; 45,173 [65%] women). During the aggregate period, patients with HZ were statistically significantly more likely to suffer a TIA: IRRs for all patients and patients aged 18 to 49 years were 1.56 (95% confidence interval [CI], 1.13-2.15) and 5.12 (95% CI, 1.37-19.10), respectively (P<.05); the respective IRRs for stroke were 1.40 (95% CI, 0.93-2.11) and 8.12 (95% CI, 0.93-71.27). In the sensitivity analysis, IRRs for TIA and stroke were statistically significantly increased regardless of age. CONCLUSION: Herpes zoster was associated with an increased risk of composite events, TIA, and stroke in adults in the period around diagnosis. More research on the HZ and vascular risk association is needed. GSK STUDY IDENTIFIER: HO-15-15771.
Authors: Parinaz Ghaswalla; Philippe Thompson-Leduc; Wendy Y Cheng; Colin Kunzweiler; Min-Jung Wang; Michael Bogart; Brandon J Patterson; Mei Sheng Duh; John Wojciehowski; Suna Park; Barbara P Yawn Journal: Chronic Obstr Pulm Dis Date: 2021-10-28
Authors: Eric Yuk Fai Wan; Celine Sze Ling Chui; Yuan Wang; Vanessa Wai Sei Ng; Vincent Ka Chun Yan; Francisco Tsz Tsun Lai; Xue Li; Carlos King Ho Wong; Esther Wai Yin Chan; Christina Sze Man Wong; Kathy Sze Man Leung; Michael Yuxuan Ni; Sophie Alessandra Valkenburg; Joseph Sriyal Malik Peiris; Joseph Tsz Kei Wu; Benjamin John Cowling; Darren M Ashcroft; Ivan Fan Ngai Hung; Gabriel Matthew Leung; Ian Chi Kei Wong Journal: Lancet Reg Health West Pac Date: 2022-02-02
Authors: Brandon J Patterson; Philip O Buck; Desmond Curran; Desirée Van Oorschot; Justin Carrico; William L Herring; Yuanhui Zhang; Jeffrey J Stoddard Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2021-05-26