Hiroyuki Kiriyama1, Hidehiro Kaneko2,3, Hidetaka Itoh1, Yuriko Yoshida1, Koki Nakanishi1, Yoshiko Mizuno1, Masao Daimon1,4, Hiroyuki Morita1, Yutaka Yatomi4, Issei Komuro1. 1. The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan. 2. The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan. kanekohidehiro@gmail.com. 3. The Department of Advanced Cardiology, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. kanekohidehiro@gmail.com. 4. The Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
Abstract
BACKGROUND: Risk factors for renal function deterioration in the general population are not fully understood. We aimed to clarify the determinants of estimated glomerular filtration rate (eGFR) decline using a community-based cohort. METHODS AND RESULTS: Among 3217 subjects who underwent repeated health check-ups, we excluded 478 subjects with eGFR ≤ 60 mL/min/1.73 m2 and examined 2739 subjects. EGFR decline rate was calculated from the difference in eGFR between the first and last visits. EGFR decline, which was defined as a drop in GFR accompanied by a 25% or greater drop in eGFR from baseline and/or a sustained decline of more than 5 mL/min/1.73 m2/year, was observed in 209 subjects (7.6%). Anemia according to the WHO definition (16.7% vs. 11.7%, p = 0.03), and proteinuria (3.3% vs. 0.8%, p < 0.001) at baseline were more commonly observed in subjects with eGFR decline. Multivariable logistic regression analysis showed that anemia and proteinuria were independently associated with eGFR decline. CONCLUSION: Anemia and proteinuria were closely related to eGFR decline, which suggests that we should consider these parameters as risk factors of the development of renal function deterioration even in the general population.
BACKGROUND: Risk factors for renal function deterioration in the general population are not fully understood. We aimed to clarify the determinants of estimated glomerular filtration rate (eGFR) decline using a community-based cohort. METHODS AND RESULTS: Among 3217 subjects who underwent repeated health check-ups, we excluded 478 subjects with eGFR ≤ 60 mL/min/1.73 m2 and examined 2739 subjects. EGFR decline rate was calculated from the difference in eGFR between the first and last visits. EGFR decline, which was defined as a drop in GFR accompanied by a 25% or greater drop in eGFR from baseline and/or a sustained decline of more than 5 mL/min/1.73 m2/year, was observed in 209 subjects (7.6%). Anemia according to the WHO definition (16.7% vs. 11.7%, p = 0.03), and proteinuria (3.3% vs. 0.8%, p < 0.001) at baseline were more commonly observed in subjects with eGFR decline. Multivariable logistic regression analysis showed that anemia and proteinuria were independently associated with eGFR decline. CONCLUSION:Anemia and proteinuria were closely related to eGFR decline, which suggests that we should consider these parameters as risk factors of the development of renal function deterioration even in the general population.
Authors: B R Hemmelgarn; J Zhang; B J Manns; M Tonelli; E Larsen; W A Ghali; D A Southern; K McLaughlin; G Mortis; B F Culleton Journal: Kidney Int Date: 2006-03-08 Impact factor: 10.612
Authors: Ting-Yuan David Cheng; Sung-Feng Wen; Brad C Astor; Xuguang Grant Tao; Jonathan M Samet; Chi Pang Wen Journal: Am J Kidney Dis Date: 2008-08-15 Impact factor: 8.860
Authors: Mark J Sarnak; Andrew S Levey; Anton C Schoolwerth; Josef Coresh; Bruce Culleton; L Lee Hamm; Peter A McCullough; Bertram L Kasiske; Ellie Kelepouris; Michael J Klag; Patrick Parfrey; Marc Pfeffer; Leopoldo Raij; David J Spinosa; Peter W Wilson Journal: Circulation Date: 2003-10-28 Impact factor: 29.690