Arpita Das1,2, Robert G Cumming2,3,4,5, Vasi Naganathan4, Fiona Blyth4, Rosilene V Ribeiro1, David G Le Couteur3,4, David J Handelsman3, Louise M Waite4, Stephen J Simpson1, Vasant Hirani1,3,4. 1. School of Life and Environmental Science Charles Perkins Centre, University of Sydney, New South Wales. 2. ARC Centre of Excellence in Population Ageing Research (CEPAR), University of New South Wales. 3. ANZAC Research Institute, University of Sydney and Concord Hospital, New South Wales. 4. Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, New South Wales. 5. School of Public Health, University of Sydney, New South Wales, Australia.
Abstract
BACKGROUND: The objective of the study is to evaluate the prospective associations between antioxidant intake and incident frailty among older Australian men aged ≥75 years. METHODS: Seven hundred and ninety-four men participated in a detailed diet history interview at the Concord Health and Ageing in Men Project (CHAMP) study third wave (considered baseline nutrition here) and 781 men participated at the fourth wave (considered 3-year follow-up here). The main outcome measurement was incident frailty at 3-year follow-up, using the Cardiovascular Health Study definition. Dietary adequacy of antioxidant intake was assessed by comparing participants' median intakes of four dietary antioxidants (vitamin A, E, C, and zinc) to the nutrient reference values (NRVs). Attainment of the NRVs was incorporated into a dichotomized variable "poor" (meeting ≤2 antioxidants) or "good" (meeting ≥3 antioxidants) as the independent variable using the cut-point method. Also, intakes of each individual dietary antioxidant at baseline nutrition were categorized into quartiles. Analyses were performed using multinomial logistic regression. RESULTS: Incidence of pre-frailty was 53.0% and frailty was 6.4% at 3-year follow-up. Poor dietary antioxidant intake (meeting ≤2) at baseline nutrition was associated with incident frailty at 3-year follow-up in unadjusted (OR: 2.59 [95% CI: 1.47, 4.59, p = .001]) and adjusted (OR: 2.46 [95% CI: 1.10, 5.51, p = .03]) analyses. The lowest quartile of vitamin E intake (<7.08 mg/d) was significantly associated with incident frailty (OR: 2.46 [95% CI: 1.01, 6.00, p = .05]). CONCLUSIONS: Poor antioxidant intake, particularly vitamin E, is a plausible factor associated with incident frailty among older men. This supports the need for clinical trials of diets rich in antioxidants or possibly low-dose antioxidant supplements, for prevention of frailty.
BACKGROUND: The objective of the study is to evaluate the prospective associations between antioxidant intake and incident frailty among older Australian men aged ≥75 years. METHODS: Seven hundred and ninety-four men participated in a detailed diet history interview at the Concord Health and Ageing in Men Project (CHAMP) study third wave (considered baseline nutrition here) and 781 men participated at the fourth wave (considered 3-year follow-up here). The main outcome measurement was incident frailty at 3-year follow-up, using the Cardiovascular Health Study definition. Dietary adequacy of antioxidant intake was assessed by comparing participants' median intakes of four dietary antioxidants (vitamin A, E,C, and zinc) to the nutrient reference values (NRVs). Attainment of the NRVs was incorporated into a dichotomized variable "poor" (meeting ≤2 antioxidants) or "good" (meeting ≥3 antioxidants) as the independent variable using the cut-point method. Also, intakes of each individual dietary antioxidant at baseline nutrition were categorized into quartiles. Analyses were performed using multinomial logistic regression. RESULTS: Incidence of pre-frailty was 53.0% and frailty was 6.4% at 3-year follow-up. Poor dietary antioxidant intake (meeting ≤2) at baseline nutrition was associated with incident frailty at 3-year follow-up in unadjusted (OR: 2.59 [95% CI: 1.47, 4.59, p = .001]) and adjusted (OR: 2.46 [95% CI: 1.10, 5.51, p = .03]) analyses. The lowest quartile of vitamin E intake (<7.08 mg/d) was significantly associated with incident frailty (OR: 2.46 [95% CI: 1.01, 6.00, p = .05]). CONCLUSIONS: Poor antioxidant intake, particularly vitamin E, is a plausible factor associated with incident frailty among older men. This supports the need for clinical trials of diets rich in antioxidants or possibly low-dose antioxidant supplements, for prevention of frailty.
Authors: Nada Almohaisen; Matthew Gittins; Chris Todd; Jana Sremanakova; Anne Marie Sowerbutts; Amal Aldossari; Asrar Almutairi; Debra Jones; Sorrel Burden Journal: Nutrients Date: 2022-04-07 Impact factor: 6.706
Authors: Ana Moradell; Ángel Iván Fernández-García; David Navarrete-Villanueva; Lucía Sagarra-Romero; Eva Gesteiro; Jorge Pérez-Gómez; Irene Rodríguez-Gómez; Ignacio Ara; Jose A Casajús; Germán Vicente-Rodríguez; Alba Gómez-Cabello Journal: Nutrients Date: 2021-04-08 Impact factor: 5.717
Authors: Mary Ni Lochlainn; Natalie J Cox; Thomas Wilson; Richard P G Hayhoe; Sheena E Ramsay; Antoneta Granic; Masoud Isanejad; Helen C Roberts; Daisy Wilson; Carly Welch; Christopher Hurst; Janice L Atkins; Nuno Mendonça; Katy Horner; Esme R Tuttiett; Yvie Morgan; Phil Heslop; Elizabeth A Williams; Claire J Steves; Carolyn Greig; John Draper; Clare A Corish; Ailsa Welch; Miles D Witham; Avan A Sayer; Sian Robinson Journal: Nutrients Date: 2021-07-09 Impact factor: 5.717