Maurice A Asouzu1, Michelle Shroyer1, John S Graham1, Linda Wilkinson1, David P Galloway2, Colin A Martin3. 1. Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham. 2. Department of Pediatrics Division of Gastroenterology, Hematology, and Nutrition, University of Alabama at Birmingham. 3. Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham. Electronic address: Colin.Martin@childrensal.org.
Abstract
BACKGROUND/ PURPOSE: Although pediatric intestinal failure (IF) is now a survivable diagnosis, children are still at risk for complications. Loss of venous access persists as a leading indication for intestinal transplantation. The goal of this study was to identify risk factors for loss of venous access in a pediatric intestinal failure population on long-term PN. METHODS: We identified all patients who were PN dependent. RESULTS: Patients that developed venous thrombosis had significantly more lines placed in the first 2 years of life compared to those who did not develop thrombosis. Multivariate regression analysis revealed that diagnosis (NEC and gastroschisis) and parental education were significant predictors of venous thrombosis. CONCLUSION: By identifying potential risk factors for thrombus development, interventions can be developed to improve the overall outcome in pediatric IF patients. TYPE OF STUDY: Diagnostic LEVEL OF EVIDENCE: III.
BACKGROUND/ PURPOSE: Although pediatric intestinal failure (IF) is now a survivable diagnosis, children are still at risk for complications. Loss of venous access persists as a leading indication for intestinal transplantation. The goal of this study was to identify risk factors for loss of venous access in a pediatric intestinal failure population on long-term PN. METHODS: We identified all patients who were PN dependent. RESULTS:Patients that developed venous thrombosis had significantly more lines placed in the first 2 years of life compared to those who did not develop thrombosis. Multivariate regression analysis revealed that diagnosis (NEC and gastroschisis) and parental education were significant predictors of venous thrombosis. CONCLUSION: By identifying potential risk factors for thrombus development, interventions can be developed to improve the overall outcome in pediatric IF patients. TYPE OF STUDY: Diagnostic LEVEL OF EVIDENCE: III.