OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated respiratory depression as a pathophysiological mechanism. The brain regions responsible for a seizure's inducing respiratory depression are unclear-the respiratory nuclei in the brainstem are thought to be involved, but involvement of forebrain structures is not yet understood. The aim of this study was to analyze intracranial EEGs in combination with the results of respiratory monitoring to investigate the relationship between seizure spread to specific mesial temporal brain regions and the onset of respiratory dysfunction and apnea. METHODS: The authors reviewed all invasive electroencephalographic studies performed at Northwestern Memorial Hospital (Chicago) since 2010 to identify those cases in which 1) multiple mesial temporal electrodes (amygdala and hippocampal) were placed, 2) seizures were captured, and 3) patients' respiration was monitored. They identified 8 investigations meeting these criteria in patients with temporal lobe epilepsy, and these investigations yielded data on a total of 22 seizures for analysis. RESULTS: The onset of ictal apnea associated with each seizure was highly correlated with seizure spread to the amygdala. Onset of apnea occurred 2.7 ± 0.4 (mean ± SEM) seconds after the spread of the seizure to the amygdala, which was significantly earlier than after spread to the hippocampus (10.2 ± 0.7 seconds; p < 0.01). CONCLUSIONS: The findings suggest that activation of amygdalar networks is correlated with central apnea during seizures. This study builds on the authors' prior work that demonstrates a role for the amygdala in voluntary respiratory control and suggests a further role in dysfunctional breathing states seen during seizures, with implications for SUDEP pathophysiology.
OBJECTIVE: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated respiratory depression as a pathophysiological mechanism. The brain regions responsible for a seizure's inducing respiratory depression are unclear-the respiratory nuclei in the brainstem are thought to be involved, but involvement of forebrain structures is not yet understood. The aim of this study was to analyze intracranial EEGs in combination with the results of respiratory monitoring to investigate the relationship between seizure spread to specific mesial temporal brain regions and the onset of respiratory dysfunction and apnea. METHODS: The authors reviewed all invasive electroencephalographic studies performed at Northwestern Memorial Hospital (Chicago) since 2010 to identify those cases in which 1) multiple mesial temporal electrodes (amygdala and hippocampal) were placed, 2) seizures were captured, and 3) patients' respiration was monitored. They identified 8 investigations meeting these criteria in patients with temporal lobe epilepsy, and these investigations yielded data on a total of 22 seizures for analysis. RESULTS: The onset of ictal apnea associated with each seizure was highly correlated with seizure spread to the amygdala. Onset of apnea occurred 2.7 ± 0.4 (mean ± SEM) seconds after the spread of the seizure to the amygdala, which was significantly earlier than after spread to the hippocampus (10.2 ± 0.7 seconds; p < 0.01). CONCLUSIONS: The findings suggest that activation of amygdalar networks is correlated with central apnea during seizures. This study builds on the authors' prior work that demonstrates a role for the amygdala in voluntary respiratory control and suggests a further role in dysfunctional breathing states seen during seizures, with implications for SUDEP pathophysiology.
Authors: YuJaung Kim; Eduardo Bravo; Caitlin K Thirnbeck; Lori A Smith-Mellecker; Se Hee Kim; Brian K Gehlbach; Linda C Laux; Xiuqiong Zhou; Douglas R Nordli; George B Richerson Journal: J Clin Invest Date: 2018-02-12 Impact factor: 14.808
Authors: Haleigh R Smith; Nicole K Leibold; Daniel A Rappoport; Callie M Ginapp; Benton S Purnell; Nicole M Bode; Stephanie L Alberico; Young-Cho Kim; Enrica Audero; Cornelius T Gross; Gordon F Buchanan Journal: J Neurosci Date: 2018-01-29 Impact factor: 6.167
Authors: Nuria Lacuey; Bilal Zonjy; Johnson P Hampson; M R Sandhya Rani; Anita Zaremba; Rup K Sainju; Brian K Gehlbach; Stephan Schuele; Daniel Friedman; Orrin Devinsky; Maromi Nei; Ronald M Harper; Luke Allen; Beate Diehl; John J Millichap; Lisa Bateman; Mark A Granner; Deidre N Dragon; George B Richerson; Samden D Lhatoo Journal: Epilepsia Date: 2018-01-16 Impact factor: 5.864
Authors: Sung-Yon Kim; Avishek Adhikari; Soo Yeun Lee; James H Marshel; Christina K Kim; Caitlin S Mallory; Maisie Lo; Sally Pak; Joanna Mattis; Byung Kook Lim; Robert C Malenka; Melissa R Warden; Rachael Neve; Kay M Tye; Karl Deisseroth Journal: Nature Date: 2013-03-20 Impact factor: 49.962
Authors: Ariane E Rhone; Christopher K Kovach; Gail Is Harmata; Alyssa W Sullivan; Daniel Tranel; Michael A Ciliberto; Matthew A Howard; George B Richerson; Mitchell Steinschneider; John A Wemmie; Brian J Dlouhy Journal: JCI Insight Date: 2020-03-26
Authors: Wen Wei Yan; Maya Xia; Jeremy Chiang; Alyssa Levitt; Nicole Hawkins; Jennifer Kearney; Geoffrey T Swanson; Dane Chetkovich; William P Nobis Journal: eNeuro Date: 2021-06-17