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Literature DB >> 30952063

Teneurins and latrophilins: two giants meet at the synapse.

Abstract

Teneurins and latrophilins are both conserved families of cell adhesion proteins that mediate cellular communication and play critical roles in embryonic and neural development. However, their mechanisms of action remain poorly understood. In the past several years, three-dimensional structures of teneurins and latrophilins have been reported at atomic resolutions and revealed distinct protein folds and unique structural features. In this review, we discuss these structures which, together with structure-guided biochemical and functional analyses, provide hints for the mechanisms of trans-cellular communication at the synapse and other cell-cell contact sites.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2019 PMID： 30952063 PMCID： PMC6677252 DOI： 10.1016/j.sbi.2019.01.028

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

75 in total

1. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors.

Authors: V G Lelianova; B A Davletov; A Sterling; M A Rahman; E V Grishin; N F Totty; Y A Ushkaryov
Journal: J Biol Chem Date: 1997-08-22 Impact factor: 5.157

2. Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.

Authors: Sally E Doyle; Matthew J Scholz; Kevin A Greer; Antony D Hubbard; Diana K Darnell; Parker B Antin; Scott E Klewer; Raymond B Runyan
Journal: Dev Dyn Date: 2006-12 Impact factor: 3.780

3. A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.

Authors: Ines Liebscher; Julia Schön; Sarah C Petersen; Liane Fischer; Nina Auerbach; Lilian Marie Demberg; Amit Mogha; Maxi Cöster; Kay-Uwe Simon; Sven Rothemund; Kelly R Monk; Torsten Schöneberg
Journal: Cell Rep Date: 2014-12-18 Impact factor: 9.423

4. Teneurin-2 is expressed in tissues that regulate limb and somite pattern formation and is induced in vitro and in situ by FGF8.

Authors: R P Tucker; R Chiquet-Ehrismann; M P Chevron; D Martin; R J Hall; B P Rubin
Journal: Dev Dyn Date: 2001-01 Impact factor: 3.780

5. Tena, a Drosophila gene related to tenascin, shows selective transcript localization.

Authors: S Baumgartner; R Chiquet-Ehrismann
Journal: Mech Dev Date: 1993-03 Impact factor: 1.882

6. Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.

Authors: Fanomezana M Ranaivoson; Qun Liu; Francesca Martini; Francesco Bergami; Sventja von Daake; Sheng Li; David Lee; Borries Demeler; Wayne A Hendrickson; Davide Comoletti
Journal: Structure Date: 2015-07-30 Impact factor: 5.006

Teneurins and latrophilins: two giants meet at the synapse.

1. Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors.

2. Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.

3. A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133.

4. Teneurin-2 is expressed in tissues that regulate limb and somite pattern formation and is induced in vitro and in situ by FGF8.

5. Tena, a Drosophila gene related to tenascin, shows selective transcript localization.

6. Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.

7. A role for TENM1 mutations in congenital general anosmia.

Review 8. Teneurins, TCAP, and latrophilins: roles in the etiology of mood disorders.

9. Homozygous null mutation in ODZ3 causes microphthalmia in humans.

10. The Mechanism of Regulated Release of Lasso/Teneurin-2.

Review 1. To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly.

2. Synaptic recognition molecules in development and disease.

Review 3. Teneurin Structure: Splice Variants of a Bacterial Toxin Homolog Specifies Synaptic Connections.

4. Latrophilin GPCR signaling mediates synapse formation.

Review 5. Teneurins: Role in Cancer and Potential Role as Diagnostic Biomarkers and Targets for Therapy.

6. Engineered synaptic tools reveal localized cAMP signaling in synapse assembly.