Literature DB >> 30952041

Recent advances in the development of HBV capsid assembly modulators.

Bhavitavya Nijampatnam1, Dennis C Liotta2.   

Abstract

Hepatitis B virus (HBV) infections represent a significant burden on global public health. Current HBV treatments using nucleos(t)ide analogs (NAs) and PEG interferons cannot fully alleviate this burden as they do not affect the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence. Capsid assembly modulators (CAMs) disrupt the encapsidation of pre-genomic RNA and can cause nucleocapsid disassembly, thereby affecting multiple steps of HBV replication and reduction of cccDNA pools. This review provides a concise overview of the development of CAMs and the progress achieved in understanding their interactions with HBV core proteins.
Copyright © 2019. Published by Elsevier Ltd.

Entities:  

Year:  2019        PMID： 30952041     DOI： 10.1016/j.cbpa.2019.02.009

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  17 in total

1.  The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly.

Authors:  Andrew G Cole; Steven G Kultgen; Nagraj Mani; Andrzej Ardzinski; Kristi Yi Fan; Emily P Thi; Bruce D Dorsey; Kim Stever; Tim Chiu; Sunny Tang; Owen Daly; Janet R Phelps; Troy Harasym; Andrea Olland; Robert K Suto; Michael J Sofia
Journal:  RSC Med Chem       Date:  2022-01-19

2.  4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators.

Authors:  Nicky Hwang; Haiqun Ban; Shuo Wu; Kelly McGuire; Ellen Hernandez; Junjun Chen; Qiong Zhao; Manasa Suresh; Benjamin Blass; Usha Viswanathan; John Kulp; Jinhong Chang; Jason Clement; Stephan Menne; Ju-Tao Guo; Yanming Du
Journal:  Bioorg Med Chem Lett       Date:  2021-12-31       Impact factor: 2.823

Review 3.  Novel therapeutic strategies for chronic hepatitis B.

Authors:  Sandra Phillips; Ravi Jagatia; Shilpa Chokshi
Journal:  Virulence       Date:  2022-12       Impact factor: 5.428

4.  The Mechanism of Action of Hepatitis B Virus Capsid Assembly Modulators Can Be Predicted from Binding to Early Assembly Intermediates.

Authors:  Anna Pavlova; Leda Bassit; Bryan D Cox; Maksym Korablyov; Christophe Chipot; Dharmeshkumar Patel; Diane L Lynch; Franck Amblard; Raymond F Schinazi; James C Gumbart
Journal:  J Med Chem       Date:  2022-03-15       Impact factor: 8.039

Review 5.  Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B.

Authors:  Usha Viswanathan; Nagraj Mani; Zhanying Hu; Haiqun Ban; Yanming Du; Jin Hu; Jinhong Chang; Ju-Tao Guo
Journal:  Antiviral Res       Date:  2020-08-17       Impact factor: 5.970

6.  Sulfamoylbenzamide-based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication.

Authors:  Yeon Hee Lee; Hyeon-Min Cha; Jun Yeon Hwang; So Yeong Park; Avinash G Vishakantegowda; Ali Imran; Joo-Youn Lee; Yoon-Sun Yi; Sangmi Jun; Ga Hyeon Kim; Hyo Jin Kang; Sang J Chung; Meehyein Kim; Hyejin Kim; Soo Bong Han
Journal:  ACS Med Chem Lett       Date:  2021-02-02       Impact factor: 4.345

7.  Discovery and structure activity relationship of glyoxamide derivatives as anti-hepatitis B virus agents.

Authors:  Franck Amblard; Sebastien Boucle; Leda Bassit; Zhe Chen; Ozkan Sari; Bryan Cox; Kiran Verma; Tugba Ozturk; Olivia Ollinger-Russell; Raymond F Schinazi
Journal:  Bioorg Med Chem       Date:  2020-12-16       Impact factor: 3.641

8.  Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches.

Authors:  Sameera Senaweera; Haijuan Du; Huanchun Zhang; Karen A Kirby; Philip R Tedbury; Jiashu Xie; Stefan G Sarafianos; Zhengqiang Wang
Journal:  Viruses       Date:  2021-04-27       Impact factor: 5.818

9.  Combination Therapy of RNA Interference and Small Molecules for Treating Hepatitis B Virus Infection.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-05-19       Impact factor: 4.632

10.  Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation.

Authors:  Shishan Wang; Marie-Laure Fogeron; Maarten Schledorn; Marie Dujardin; Susanne Penzel; Dara Burdette; Jan Martin Berke; Michael Nassal; Lauriane Lecoq; Beat H Meier; Anja Böckmann
Journal:  Front Mol Biosci       Date:  2019-08-08
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