Annabelle Bédard1, Xavier Basagaña1, Josep M Anto1, Judith Garcia-Aymerich1, Philippe Devillier2, Sylvie Arnavielhe3, Anna Bedbrook4, Gabrielle L Onorato4, Wienczyslawa Czarlewski5, Ruth Murray6, Rute Almeida7, Joao Fonseca7, Elisio Costa8, Joao Malva9, Mario Morais-Almeida10, Ana Margarida Pereira11, Ana Todo-Bom12, Enrica Menditto13, Cristiana Stellato14, Maria Teresa Ventura15, Alvaro A Cruz16, Rafaël Stelmach17, Jane da Silva18, Désirée Larenas-Linnemann19, José M Fuentes-Pérez20, Yunuen R Huerta-Villalobos20, Regina Emuzyte21, Violeta Kvedariene22, Arunas Valiulis23, Piotr Kuna24, Boleslaw Samolinski25, Ludger Klimek26, Ralph Mösges27, Oliver Pfaar28, Sara Shamai27, Isabelle Annesi-Maesano29, Isabelle Bosse30, Pascal Demoly31, Jean-François Fontaine32, Vicky Cardona33, Joaquim Mullol34, Antonio Valero35, Regina E Roller-Wirnsberger36, Peter Valentin Tomazic37, Niels H Chavannes38, Wytske J Fokkens39, Sietze Reitsma39, Mike Bewick40, Dermot Ryan41, Aziz Sheikh42, Tari Haahtela43, Sanna Toppila-Salmi43, Erkka Valovirta44, Michael Makris45, Nikos G Papadopoulos46, Emmanuel P Prokopakis47, Fotis Psarros48, Cemal Cingi49, Bilun Gemicioğlu50, Arzu Yorgancioglu51, Sinthia Bosnic-Anticevich52, Robyn E O'Hehir53, Claus Bachert54, Peter W Hellings55, Benoit Pugin56, Carsten Bindslev-Jensen57, Esben Eller57, Ingrid Kull58, Erik Melén59, Magnus Wickman60, Gert De Vries61, Michiel van Eerd61, Ioana Agache62, Ignacio J Ansotegui63, Mark S Dykewicz64, Thomas Casale65, Dana Wallace66, Susan Waserman67, Daniel Laune3, Jean Bousquet68. 1. ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain. 2. UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France. 3. KYomed INNOV, Montpellier, France. 4. MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France. 5. Medical Consulting Czarlewski, Levallois, France. 6. Medical Communications Consultant, MedScript, Dundalk, and OPC, Cambridge, United Kingdom. 7. Center for Health Technology and Services Research-CINTESIS, Faculdade de Medicina, Universidade do Porto, and Medida, Porto, Portugal. 8. UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal. 9. Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, and the Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal. 10. Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal. 11. Allergy Unit, CUF-Porto Hospital and Institute, and the Center for Research in Health Technologies and information systems CINTESIS, Universidade do Porto, Porto, Portugal. 12. Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal. 13. CIRFF, Federico II University, Naples, Italy. 14. Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy. 15. Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy. 16. ProAR-Nucleo de Excelencia em Asma, Federal University of Bahia, and the WHO GARD Planning Group, Brazil. 17. Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. 18. Department of Internal Medicine and Allergy Clinic of Professor Polydoro Ernani de São Thiago University Hospital, Federal University of Santa Catarina (UFSC), Florianopolis, Brazil. 19. Center of Excellence in Asthma and Allergy, Hospital Médica Sur, México City, Mexico. 20. Hospital General Region 1, Dr Carlos Mc Gregor Sanchez Navarro" IMSS, Mexico City, Mexico. 21. Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania. 22. Faculty of Medicine, Vilnius University, Vilnius, Lithuania. 23. Vilnius University Institute of Clinical Medicine, Clinic of Children's Diseases, and the Institute of Health Sciences, Department of Public Health, Vilnius, Lithuania; European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium. 24. Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland. 25. Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland. 26. Center for Rhinology and Allergology, Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 27. Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, and CRI-Clinical Research International, Hamburg, Germany. 28. Department of Otorhinolaryngology, Head and Neck Surgery, Section for Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität, Marburg, Germany. 29. Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France. 30. Allergist, La Rochelle, France. 31. Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France. 32. Allergist, Reims, France. 33. Allergy Section, Department of Internal Medicine, Hospital Vall'dHebron & ARADyAL Research Network, Barcelona, Spain. 34. Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain. 35. Pneumology and Allergy Department CIBERES and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, University of Barcelona, Barcelona, Spain. 36. Department of Internal Medicine, Medical University of Graz, Graz, Austria. 37. Department of ENT, Medical University of Graz, Graz, Austria. 38. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. 39. Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, the Netherlands. 40. iQ4U Consultants, London, United Kingdom. 41. Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom. 42. Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom. 43. Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland. 44. Department of Lung Diseases and Clinical Immunology, University of Turku and Terveystalo allergy clinic, Turku, Finland. 45. Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece. 46. Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, and UK Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou", University of Athens, Athens, Greece. 47. Department of Otorhinolaryngology University of Crete School of Medicine, Heraklion, Greece. 48. Allergy Department, Athens Naval Hospital, Athens, Greece. 49. Eskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey. 50. Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey. 51. Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa (and the GARD Executive Committee), Manisa, Turkey. 52. Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia; Woolcock Emphysema Centre and Local Health District, Glebe, Australia. 53. Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, and the Department of Immunology, Monash University, Melbourne, Australia. 54. Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium. 55. Department of Otorhinolaryngology, University Hospitals Leuven, and the Academic Medical Center, University of Amsterdam, and Euforea, Brussels, Belgium. 56. European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Brussels, Belgium. 57. Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark. 58. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, and Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 59. Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 60. Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden. 61. Peercode BV, Geldermalsen, the Netherlands. 62. Transylvania University Brasov, Brasov, Romania. 63. Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain. 64. Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Mo. 65. Division of Allergy/Immunology, University of South Florida, Tampa, Fla. 66. Nova Southeastern University, Fort Lauderdale, Fla. 67. Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada. 68. MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France; University Hospital, Montpellier, France; INSERM U 1168, VIMA: Ageing and chronic diseases Epidemiological and Public Health Approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, and Euforea, Brussels, Belgium. Electronic address: jean.bousquet@orange.f.
Abstract
BACKGROUND: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. OBJECTIVES: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. METHODS: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H1-antihistamines were studied. RESULTS: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H1-antihistamines were found. CONCLUSIONS: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.
BACKGROUND: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. OBJECTIVES: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. METHODS: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H1-antihistamines were studied. RESULTS: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H1-antihistamines were found. CONCLUSIONS: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.
Authors: Ayşe Arzu Yorgancıoğlu; Bilun Gemicioğlu; Cemal Cingi; Ömer Kalaycı; Ali Fuat Kalyoncu; Claus Bachert; Peter Hellings; Oliver Pfaar; Holger J Schünemann; Dana Wallace; Anna Bedbrook; Wienczyslawa Czarlewski; Jean Bousquet Journal: Turk Thorac J Date: 2020-03-01
Authors: J Jean Bousquet; Holger J Schünemann; Alkis Togias; Marina Erhola; Peter W Hellings; Torsten Zuberbier; Ioana Agache; Ignacio J Ansotegui; Josep M Anto; Claus Bachert; Sven Becker; Martin Bedolla-Barajas; Michael Bewick; Sinthia Bosnic-Anticevich; Isabelle Bosse; Louis P Boulet; Jean Marc Bourrez; Guy Brusselle; Niels Chavannes; Elisio Costa; Alvaro A Cruz; Wienczyslawa Czarlewski; Wytske J Fokkens; Joao A Fonseca; Mina Gaga; Tari Haahtela; Maddalena Illario; Ludger Klimek; Piotr Kuna; Violeta Kvedariene; L T T Le; Desiree Larenas-Linnemann; Daniel Laune; Olga M Lourenço; Enrica Menditto; Joaquin Mullol; Yashitaka Okamoto; Nikos Papadopoulos; Nhân Pham-Thi; Robert Picard; Hilary Pinnock; Nicolas Roche; Regina E Roller-Wirnsberger; Christine Rolland; Boleslaw Samolinski; Aziz Sheikh; Sanna Toppila-Salmi; Ioanna Tsiligianni; Arunas Valiulis; Erkka Valovirta; Tuula Vasankari; Maria-Teresa Ventura; Samantha Walker; Sian Williams; Cezmi A Akdis; Isabella Annesi-Maesano; Sylvie Arnavielhe; Xavier Basagana; Eric Bateman; Anna Bedbrook; K S Bennoor; Samuel Benveniste; Karl C Bergmann; Slawomir Bialek; Nils Billo; Carsten Bindslev-Jensen; Leif Bjermer; Hubert Blain; Mateo Bonini; Philippe Bonniaud; Jacques Bouchard; Vitalis Briedis; Christofer E Brightling; Jan Brozek; Roland Buhl; Roland Buonaiuto; Giorgo W Canonica; Victoria Cardona; Ana M Carriazo; Warner Carr; Christine Cartier; Thomas Casale; Lorenzo Cecchi; Alfonso M Cepeda Sarabia; Eka Chkhartishvili; Derek K Chu; Cemal Cingi; Elaine Colgan; Jaime Correia de Sousa; Anne Lise Courbis; Adnan Custovic; Biljana Cvetkosvki; Gennaro D'Amato; Jane da Silva; Carina Dantas; Dejand Dokic; Yves Dauvilliers; Antoni Dedeu; Giulia De Feo; Philippe Devillier; Stefania Di Capua; Marc Dykewickz; Ruta Dubakiene; Motohiro Ebisawa; Yaya El-Gamal; Esben Eller; Regina Emuzyte; John Farrell; Antjie Fink-Wagner; Alessandro Fiocchi; Jean F Fontaine; Bilun Gemicioğlu; Peter Schmid-Grendelmeir; Amiran Gamkrelidze; Judith Garcia-Aymerich; Maximiliano Gomez; Sandra González Diaz; Maia Gotua; Nick A Guldemond; Maria-Antonieta Guzmán; Jawad Hajjam; John O'B Hourihane; Marc Humbert; Guido Iaccarino; Despo Ierodiakonou; Maddalena Illario; Juan C Ivancevich; Guy Joos; Ki-Suck Jung; Marek Jutel; Igor Kaidashev; Omer Kalayci; Przemyslaw Kardas; Thomas Keil; Mussa Khaitov; Nikolai Khaltaev; Jorg Kleine-Tebbe; Marek L Kowalski; Vicky Kritikos; Inger Kull; Lisa Leonardini; Philip Lieberman; Brian Lipworth; Karin C Lodrup Carlsen; Claudia C Loureiro; Renaud Louis; Alpana Mair; Gert Marien; Bassam Mahboub; Joao Malva; Patrick Manning; Esteban De Manuel Keenoy; Gailen D Marshall; Mohamed R Masjedi; Jorge F Maspero; Eve Mathieu-Dupas; Poalo M Matricardi; Eric Melén; Elisabete Melo-Gomes; Eli O Meltzer; Enrica Menditto; Jacques Mercier; Neven Miculinic; Florin Mihaltan; Branislava Milenkovic; Giuliana Moda; Maria-Dolores Mogica-Martinez; Yousser Mohammad; Steve Montefort; Ricardo Monti; Mario Morais-Almeida; Ralf Mösges; Lars Münter; Antonella Muraro; Ruth Murray; Robert Naclerio; Luigi Napoli; Leila Namazova-Baranova; Hugo Neffen; Kristoff Nekam; Angelo Neou; Enrico Novellino; Dieudonné Nyembue; Robin O'Hehir; Ken Ohta; Kimi Okubo; Gabrielle Onorato; Solange Ouedraogo; Isabella Pali-Schöll; Susanna Palkonen; Peter Panzner; Hae-Sim Park; Jean-Louis Pépin; Ana-Maria Pereira; Oliver Pfaar; Ema Paulino; Jim Phillips; Robert Picard; Davor Plavec; Ted A Popov; Fabienne Portejoie; David Price; Emmanuel P Prokopakis; Benoit Pugin; Filip Raciborski; Rojin Rajabian-Söderlund; Sietze Reitsma; Xavier Rodo; Antonino Romano; Nelson Rosario; Menahenm Rottem; Dermot Ryan; Johanna Salimäki; Mario M Sanchez-Borges; Juan-Carlos Sisul; Dirceu Solé; David Somekh; Talant Sooronbaev; Milan Sova; Otto Spranger; Cristina Stellato; Rafael Stelmach; Charlotte Suppli Ulrik; Michel Thibaudon; Teresa To; Ana Todo-Bom; Peter V Tomazic; Antonio A Valero; Rudolph Valenta; Marylin Valentin-Rostan; Rianne van der Kleij; Olivier Vandenplas; Giorgio Vezzani; Frédéric Viart; Giovanni Viegi; Dana Wallace; Martin Wagenmann; De Y Wang; Susan Waserman; Magnus Wickman; Dennis M Williams; Gary Wong; Piotr Wroczynski; Panayiotis K Yiallouros; Arzu Yorgancioglu; Osman M Yusuf; Heahter J Zar; Stéphane Zeng; Mario Zernotti; Luo Zhang; Nan S Zhong; Mihaela Zidarn Journal: Clin Transl Allergy Date: 2019-09-09 Impact factor: 5.871
Authors: Sinthia Bosnic-Anticevich; Peter Smith; Michael Abramson; Charlotte Mary Hespe; Menai Johnson; Rodney Stosic; David B Price Journal: BMJ Open Date: 2020-11-24 Impact factor: 2.692
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Authors: Dimitrios I Mitsias; Maria V Dimou; John Lakoumentas; Konstantinos Alevizopoulos; Bernardo Sousa-Pinto; Joao A Fonseca; Jean Bousquet; Nikolaos G Papadopoulos Journal: Clin Transl Allergy Date: 2020-03-13 Impact factor: 5.871
Authors: Stephanie Dramburg; María Marchante Fernández; Ekaterina Potapova; Paolo Maria Matricardi Journal: Front Immunol Date: 2020-09-10 Impact factor: 7.561