Literature DB >> 30951663

Does Autophagy Promote Longevity? It Depends.

Marzia Savini1, Meng C Wang2.   

Abstract

Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID: 30951663     DOI: 10.1016/j.cell.2019.03.021

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  5 in total

1.  Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension.

Authors:  Kai Chen; Zhongjie Sun
Journal:  J Mol Med (Berl)       Date:  2019-10-19       Impact factor: 4.599

2.  A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence.

Authors:  Howard H Chen; Zehedina Khatun; Lan Wei; Choukri Mekkaoui; Dakshesh Patel; Sally Ji Who Kim; Asma Boukhalfa; Efosa Enoma; Lin Meng; Yinching I Chen; Leena Kaikkonen; Guoping Li; Diane E Capen; Parul Sahu; Anand T N Kumar; Robert M Blanton; Hushan Yuan; Saumya Das; Lee Josephson; David E Sosnovik
Journal:  Nat Biomed Eng       Date:  2022-07-11       Impact factor: 29.234

3.  CHIR99021 Augmented the Function of Late Endothelial Progenitor Cells by Preventing Replicative Senescence.

Authors:  Vinoth Kumar Rethineswaran; Da Yeon Kim; Yeon-Ju Kim; WoongBi Jang; Seung Taek Ji; Le Thi Hong Van; Ly Thanh Truong Giang; Jong Seong Ha; Jisoo Yun; Jinsup Jung; Sang-Mo Kwon
Journal:  Int J Mol Sci       Date:  2021-04-30       Impact factor: 5.923

4.  Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics.

Authors:  Liqiang Zhou; Minfeng Huo; Xiaoqin Qian; Li Ding; Luodan Yu; Wei Feng; Xinwu Cui; Yu Chen
Journal:  J Nanobiotechnology       Date:  2021-04-20       Impact factor: 10.435

5.  Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.

Authors:  Shangyue Zhang; Yuerong Zhang; Xinyu Zhang; Chenghua Luo; Yan Cao; Dengyu Ji; Wenjing Yan; Ke Xue; Jiayin Chai; Hongyan Dai; Wen Wang
Journal:  Oxid Med Cell Longev       Date:  2020-01-25       Impact factor: 6.543

  5 in total

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