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Literature DB >> 3095127

Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage.

K Hayakawa, R R Hardy, A M Stall, L A Herzenberg, L A Herzenberg.

Abstract

Previous reconstitution studies in irradiated mice distinguished Ly-1 B from other B cells. The predominant B cell populations in spleen and lymph node are readily reconstituted from progenitors present in adult bone marrow. Ly-1 B cells, in contrast, are reconstituted from cells in peritoneum rather than bone marrow. Further studies, presented here, demonstrate that Ly-1 B populations are reconstituted from peritoneal cells that already express both surface immunoglobulin (IgM) and Ly-1, that is, Ly-1 B. Such cells reconstitute and maintain the Ly-1 B population in irradiated recipients for at least 6 months.

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Year: 1986 PMID： 3095127 DOI： 10.1002/eji.1830161021

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

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Cited

53 in total

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