Juan Marco Figueira-Gonçalves1, Rafael Golpe2, Miguel Ángel García-Bello3, Ignacio García-Talavera1, Olalla Castro-Añón2. 1. Pneumology and Thoracic Surgery Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. 2. Pneumology Service, University Hospital Lucus Augusti, Lugo, Spain. 3. Division of Clinical Epidemiology and Biostatistics, Research Unit, University Hospital Nuestra Señora de la Candelaria (HUNSC) and Primary Care Management, Santa Cruz de Tenerife, Spain.
Abstract
BACKGROUND: Comorbidities are a major cause of death in chronic obstructive pulmonary disease (COPD). The COPD-comorbidity test (COTE) index was designed to measure comorbidity burden in this disease. The objective of this study was to compare the capability of COTE and the non-COPD specific Charlson comorbidity index (CCI) to predict all-cause mortality in real-life conditions. METHODS: Retrospective observational study, carried out in two different series of consecutive COPD patients including, respectively, 790 and 439 subjects. The COTE and non-age-adjusted CCI indices were calculated and the values of the C-statistic for predicting all-cause mortality were compared for both indices. RESULTS: Median follow-up was 54 months and there were 321 deaths within this period of time. The value of the C-statistic for the CCI was significantly higher than for the COTE index in both groups. CONCLUSION: When used in real-life clinical practice, the value of the CCI to predict all-cause mortality in COPD seems higher than that of the COTE index.
BACKGROUND: Comorbidities are a major cause of death in chronic obstructive pulmonary disease (COPD). The COPD-comorbidity test (COTE) index was designed to measure comorbidity burden in this disease. The objective of this study was to compare the capability of COTE and the non-COPD specific Charlson comorbidity index (CCI) to predict all-cause mortality in real-life conditions. METHODS: Retrospective observational study, carried out in two different series of consecutive COPDpatients including, respectively, 790 and 439 subjects. The COTE and non-age-adjusted CCI indices were calculated and the values of the C-statistic for predicting all-cause mortality were compared for both indices. RESULTS: Median follow-up was 54 months and there were 321 deaths within this period of time. The value of the C-statistic for the CCI was significantly higher than for the COTE index in both groups. CONCLUSION: When used in real-life clinical practice, the value of the CCI to predict all-cause mortality in COPD seems higher than that of the COTE index.
Authors: J H Fisher; M Kolb; M Algamdi; J Morisset; K A Johannson; S Shapera; P Wilcox; T To; M Sadatsafavi; H Manganas; N Khalil; N Hambly; A J Halayko; A S Gershon; C D Fell; G Cox; C J Ryerson Journal: BMC Pulm Med Date: 2019-11-27 Impact factor: 3.317