Jan M Kitzen1, Jamie L McConaha2, Megan L Bookser3, Joseph V Pergolizzi4,5, Robert Taylor4, Robert B Raffa5,6,7. 1. Kitzen Pharmaceutical Consulting, Collegeville, Pennsylvania. 2. Duquesne University School of Pharmacy, Pittsburgh, Pennsylvania. 3. Preferred Primary Care Physicians, Pittsburgh, Pennsylvania. 4. NEMA Research, Inc., Naples, Florida. 5. Neumentum, Inc., Palo Alto, California. 6. University of Arizona College of Pharmacy, Tucson, Arizona. 7. Temple University School of Pharmacy, Philadelphia, Pennsylvania.
Abstract
WHAT IS KNOWN AND OBJECTIVE: Electronic nicotine delivery systems (ENDS) are battery-powered devices that allow nicotine and/or other substances to be inhaled in aerosolized form. e-Cigarettes (electronic cigarettes), the most commonly used ENDS, have been proposed to be smoking cessation aids. However, despite the rapid surge in their popularity, little is known about long-term health consequences of e-cigarette usage. We assess published data to see if they deliver what they promise. COMMENT: e-Cigarettes may contain uncertain quantities of various ingredients, and evidence of adulteration has been identified. Flavouring agents can alter the pharmacokinetics of nicotine and have uncertain impact on the nature of e-cigarette use (eg ab initio use vs smoking cessation). WHAT IS NEW AND CONCLUSION: Although e-cigarettes have been proposed to be a safe approach to encouraging smoking cessation, there are inconsistencies in available data. And further data are needed regarding long-term implications of primary and secondary exposure to e-cigarette products.
RCT Entities:
WHAT IS KNOWN AND OBJECTIVE: Electronic nicotine delivery systems (ENDS) are battery-powered devices that allow nicotine and/or other substances to be inhaled in aerosolized form. e-Cigarettes (electronic cigarettes), the most commonly used ENDS, have been proposed to be smoking cessation aids. However, despite the rapid surge in their popularity, little is known about long-term health consequences of e-cigarette usage. We assess published data to see if they deliver what they promise. COMMENT: e-Cigarettes may contain uncertain quantities of various ingredients, and evidence of adulteration has been identified. Flavouring agents can alter the pharmacokinetics of nicotine and have uncertain impact on the nature of e-cigarette use (eg ab initio use vs smoking cessation). WHAT IS NEW AND CONCLUSION: Although e-cigarettes have been proposed to be a safe approach to encouraging smoking cessation, there are inconsistencies in available data. And further data are needed regarding long-term implications of primary and secondary exposure to e-cigarette products.
Authors: Christian Montanari; Leslie K Kelley; Tony M Kerr; Maury Cole; Nicholas W Gilpin Journal: Psychopharmacology (Berl) Date: 2019-11-23 Impact factor: 4.530
Authors: Jolanda Palmisani; Alessia Di Gilio; Laura Palmieri; Carmelo Abenavoli; Marco Famele; Rosa Draisci; Gianluigi de Gennaro Journal: Toxics Date: 2019-11-25