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Literature DB >> 309484

In vitro growth of murine T cells. I. Production of factors necessary for T cell growth.

Abstract

Supernatants of murine lymphoid cultures stimulated with Concanavalin A contain factor(s) capable of sustaining continuous growth of murine lymphoid cells in vitro. Methods for the optimal generation of these growth factors (GM) have been defined, including number of cells required, optimal concentration of Concanavalin A, incubation time, and strain differences in GM production. With GM, cells have been grown for over 15 10-fold generations over a 2-month period. The growing cells express the theta surface marker and do not express surface Ia antigens.

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Year: 1978 PMID： 309484

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

14 in total

1. Selection of cytotoxic T lymphocytes against autologous human melanoma from lymph nodes with metastatic melanoma using repeated in vitro sensitization.

Authors: S P Leong; M E Granberry; Y M Zhou; T F Wang; T M Grogan
Journal: Clin Exp Metastasis Date: 1991 May-Jun Impact factor: 5.150

2. Activation of secondary cytotoxic lymphocytes by cell-free factors from I-region-primed and D-region-primed lymphocytes.

Authors: S Kano; K Oshimi; M Sumiya; N Gonda
Journal: Immunology Date: 1980-11 Impact factor: 7.397

3. Antigen-specific inhibition of CD4+ T-cell responses to beta-lactoglobulin by its single amino acid-substituted mutant form through T-cell receptor antagonism.

Authors: M Totsuka; S Furukawa; E Sato; A Ametani; S Kaminogawa
Journal: Cytotechnology Date: 1997 Impact factor: 2.058

4. T cells may express multiple activities: specific allohelp, cytolysis, and delayed-type hypersensitivity are expressed by a cloned T-cell line.

Authors: G Dennert; S Weiss; J F Warner
Journal: Proc Natl Acad Sci U S A Date: 1981-07 Impact factor: 11.205

5. Natural cell-mediated cytotoxicity in vitro and inhibition of tumor growth in vivo by murine lymphoid cells cultured with T cell growth factor (TCGF).

Authors: E Kedar; B L Ikejiri; E Gorelik; R B Herbermann
Journal: Cancer Immunol Immunother Date: 1982 Impact factor: 6.968

6. Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media.

Authors: J W Mier; R C Gallo
Journal: Proc Natl Acad Sci U S A Date: 1980-10 Impact factor: 11.205

In vitro growth of murine T cells. I. Production of factors necessary for T cell growth.

1. Selection of cytotoxic T lymphocytes against autologous human melanoma from lymph nodes with metastatic melanoma using repeated in vitro sensitization.

2. Activation of secondary cytotoxic lymphocytes by cell-free factors from I-region-primed and D-region-primed lymphocytes.

3. Antigen-specific inhibition of CD4+ T-cell responses to beta-lactoglobulin by its single amino acid-substituted mutant form through T-cell receptor antagonism.

4. T cells may express multiple activities: specific allohelp, cytolysis, and delayed-type hypersensitivity are expressed by a cloned T-cell line.

5. Natural cell-mediated cytotoxicity in vitro and inhibition of tumor growth in vivo by murine lymphoid cells cultured with T cell growth factor (TCGF).

6. Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media.

7. Theileriosis: cell-mediated and humoral immunity.

8. Human T lymphocytes grown in T-cell growth factor: functional attributes in MLC, CML, PLT and allogeneic suppression.

9. Immersion in the search for effective cancer immunotherapies.

10. Regression of a disseminated syngeneic solid tumor by systemic transfer of lymphoid cells expanded in interleukin 2.