Literature DB >> 30947670

Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect.

Sheng Wang1, Dexi Zhou1, Zhenyu Xu1, Jing Song1, Xueyi Qian1, Xiongwen Lv2, Jiajie Luan1.   

Abstract

The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually discovered that the essence of cell carcinogenesis is the infinite proliferation of cells caused by the disorder of cell signal transduction pathways, followed by a major shift in the concept of anti-tumor drugs research and development. The focus of research and development is shifting from traditional cytotoxic drugs to a new generation of anti-tumor drugs targeted at abnormal signaling system targets in tumor cells. In this review, we summarize the targets of anti-tumor drugs and analyse the molecular mechanisms of their effects, which lay a foundation for subsequent treatment, research and development. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Anti-tumor drug targets; cell cycle; histone deacetylase inhibitor; immune checkpoints; microRNAs; therapeutic strategies; tyrosine kinase; ubiquitinzzm321990proteasome system.

Year:  2019        PMID: 30947670     DOI: 10.2174/1389450120666190402145325

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN: 1389-4501            Impact factor:   3.465


  4 in total

1.  SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells.

Authors:  Jin-Ling Zhou; Xiu-Ying Huang; Han-Chen Qiu; Ri-Zhi Gan; Huan Zhou; Hong-Qing Zhu; Xuan-Xuan Zhang; Guo-Dong Lu; Gang Liang
Journal:  Onco Targets Ther       Date:  2020-06-23       Impact factor: 4.147

Review 2.  Antitumor Drugs and Their Targets.

Authors:  Zlatko Dembic
Journal:  Molecules       Date:  2020-12-07       Impact factor: 4.411

3.  Molecular and Immune Characteristics for Lung Adenocarcinoma Patients With ERLIN2 Overexpression.

Authors:  Yifei Liu; Pengfei Xie; Daishang Jiang; Jian Liu; Jianguo Zhang; Tingting Bian; Jiahai Shi
Journal:  Front Immunol       Date:  2020-12-07       Impact factor: 7.561

4.  Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.

Authors:  Yi Li; Feng Peng; Xiangyun Tan; Jin Wang; Yeqing Xu
Journal:  Genes Genomics       Date:  2021-08-21       Impact factor: 1.839

  4 in total

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