Literature DB >> 3094667

Are biochemical tests of thyroid function of any value in monitoring patients receiving thyroxine replacement?

W D Fraser, E M Biggart, D S O'Reilly, H W Gray, J H McKillop, J A Thomson.   

Abstract

To establish their role in monitoring patients receiving thyroxine replacement biochemical tests of thyroid function were performed in 148 hypothyroid patients studied prospectively. Measurements of serum concentrations of total thyroxine, analogue free thyroxine, total triiodothyronine, analogue free triiodothyronine, and thyroid stimulating hormone, made with a sensitive immunoradiometric assay, did not, except in patients with gross abnormalities, distinguish euthyroid patients from those who were receiving inadequate or excessive replacement. These measurements are therefore of little, if any, value in monitoring patients receiving thyroxine replacement. To stop doing thyroid function tests in these cases would result in considerable savings nationally in the cost of reagents in laboratories using commercial kits.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3094667      PMCID： PMC1341585          DOI： 10.1136/bmj.293.6550.808

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  14 in total

1.  Clinical and metabolic studies in thyroid disease.

Authors:  E J WAYNE
Journal:  Br Med J       Date:  1960-01-02

2.  Replacement dosage of L-thyroxine in hypothyroidism. A re-evaluation.

Authors:  J M Stock; M I Surks; J H Oppenheimer
Journal:  N Engl J Med       Date:  1974-03-07       Impact factor: 91.245

3.  Thyroxine replacement treatment: clinical judgment or biochemical control?

Authors:  A D Toft
Journal:  Br Med J (Clin Res Ed)       Date:  1985-07-27

Review 4.  Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications.

Authors:  P R Larsen; J E Silva; M M Kaplan
Journal:  Endocr Rev       Date:  1981       Impact factor: 19.871

5.  Total and free thyroid hormone concentrations in patients receiving maintenance replacement treatment with thyroxine.

Authors:  C J Pearce; R L Himsworth
Journal:  Br Med J (Clin Res Ed)       Date:  1984-03-03

6.  Relevance of increased serum thyroxine concentrations associated with normal serum triiodothyronine values in hypothyroid patients receiving thyroxine: a case for "tissue thyrotoxicosis".

Authors:  P E Jennings; B P O'Malley; K E Griffin; B Northover; F D Rosenthal
Journal:  Br Med J (Clin Res Ed)       Date:  1984-12-15

7.  'Chemical hyperthyroidism': the significance of elevated serum thyroxine levels in L-thyroxine treated individuals.

Authors:  M Rendell; D Salmon
Journal:  Clin Endocrinol (Oxf)       Date:  1985-06       Impact factor: 3.478

8.  Treatment of hypothyroidism: a reappraisal of thyroxine therapy.

Authors:  D Evered; E T Young; B J Ormston; R Menzies; P A Smith; R Hall
Journal:  Br Med J       Date:  1973-07-21

9.  Conflict between classifications based on free thyroxine and thyroid stimulating hormone concentrations in thyroxine-treated patients.

Authors:  S Oldfield; D B Ramsden; K E Stephens; H Barrington; R A Hall; J J Milles
Journal:  Clin Chim Acta       Date:  1985-02-15       Impact factor: 3.786

10.  The effect of minor increments in plasma thyroxine on heart rate and urinary sodium excretion.

Authors:  G M Bell; J S Sawers; J C Forfar; A Doig; A D Toft
Journal:  Clin Endocrinol (Oxf)       Date:  1983-05       Impact factor: 3.478
View more
  6 in total

1.  Mineralocorticoids in the management of primary adrenocortical insufficiency.

Authors:  M Jadoul; A Ferrant; J F De Plaen; J Crabbé
Journal:  J Endocrinol Invest       Date:  1991-02       Impact factor: 4.256

2.  Euthyroid hyperthyroxinaemia.

Authors:  V Rippere
Journal:  J R Soc Med       Date:  1988-06       Impact factor: 5.344

3.  Do abnormal thyroid stimulating hormone level values result in treatment changes? A study of patients on thyroxine in one general practice.

Authors:  P De Whalley
Journal:  Br J Gen Pract       Date:  1995-02       Impact factor: 5.386

4.  Thyroxine prescription in the community: serum thyroid stimulating hormone level assays as an indicator of undertreatment or overtreatment.

Authors:  J V Parle; J A Franklyn; K W Cross; S R Jones; M C Sheppard
Journal:  Br J Gen Pract       Date:  1993-03       Impact factor: 5.386

Review 5.  Relational Stability in the Expression of Normality, Variation, and Control of Thyroid Function.

Authors:  Rudolf Hoermann; John E M Midgley; Rolf Larisch; Johannes W Dietrich
Journal:  Front Endocrinol (Lausanne)       Date:  2016-11-07       Impact factor: 5.555

6.  Does the "Silver Bullet" Lose its Shine Over the Time? Assessment of Loss of Lithium Response in a Preliminary Sample of Bipolar Disorder Outpatients.

Authors:  M Fornaro; B Stubbs; D De Berardis; F Iasevoli; M Solmi; N Veronese; A Carano; G Perna; A De Bartolomeis
Journal:  Clin Pract Epidemiol Ment Health       Date:  2016-12-23
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.