Jun Sung Moon1, Seung Min Chung1, Sung Ho Jang2, Kyu Chang Won1, Min Cheol Chang2. 1. Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Yeungnam University. 2. Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University.
Abstract
PURPOSE: Little is known about the effects of diabetes on motor recovery after cerebral infarct. To address this, we recruited patients with corona radiata infarct and controlled for the integrity of the corticospinal tract (CST) determined using diffusion tensor tractography (DTT). METHODS: One hundred patients were recruited, and DTT was performed within 7-30 days of infarct onset. Based on the DTT findings (DTT+: CST was preserved around the infarct, DTT-: CST was interrupted by the infarct) and the presence (DM+) or absence (DM-) of diabetes, patients were divided into, DTT+/DM- (36 patients), DTT+/DM+ (19 patients), DTT-/DM- (32 patients), and DTT-/DM+ (13 patients) groups. Six months after cerebral infarct, motor function on the affected side was evaluated for each patient using the upper Motricity Index (MI), lower MI, modified Brunnstrom classification (MBC), and the functional ambulation category (FAC). RESULTS: In the patients with a DTT+ finding, no motor function scores were significantly different between the DTT+/DM- and DTT+/DM+ groups at six-month evaluation. However, in patients with DTT- finding, all motor function scores at the six-month evaluation were significantly higher in the DTT-/DM- group than in the DTT-/DM+ group. CONCLUSION: When the CST is interrupted by a corona radiata infarct, recovery of motor function in patients with diabetes is more impaired than those without diabetes.
PURPOSE: Little is known about the effects of diabetes on motor recovery after cerebral infarct. To address this, we recruited patients with corona radiata infarct and controlled for the integrity of the corticospinal tract (CST) determined using diffusion tensor tractography (DTT). METHODS: One hundred patients were recruited, and DTT was performed within 7-30 days of infarct onset. Based on the DTT findings (DTT+: CST was preserved around the infarct, DTT-: CST was interrupted by the infarct) and the presence (DM+) or absence (DM-) of diabetes, patients were divided into, DTT+/DM- (36 patients), DTT+/DM+ (19 patients), DTT-/DM- (32 patients), and DTT-/DM+ (13 patients) groups. Six months after cerebral infarct, motor function on the affected side was evaluated for each patient using the upper Motricity Index (MI), lower MI, modified Brunnstrom classification (MBC), and the functional ambulation category (FAC). RESULTS: In the patients with a DTT+ finding, no motor function scores were significantly different between the DTT+/DM- and DTT+/DM+ groups at six-month evaluation. However, in patients with DTT- finding, all motor function scores at the six-month evaluation were significantly higher in the DTT-/DM- group than in the DTT-/DM+ group. CONCLUSION: When the CST is interrupted by a corona radiata infarct, recovery of motor function in patients with diabetes is more impaired than those without diabetes.